[环孢素药物相互作用的临床评估]
[Clinical evaluation of drug interactions of cyclosporin].
作者信息
Billaud E M, Kreft-Jais C, De la Tour du Pin F, Alexandre J M
机构信息
Service de Pharmacologie clinique, Hôpital Broussais, Paris.
出版信息
Presse Med. 1988 Dec 3;17(43):2293-5.
PMID:2905455
Abstract
Cyclosporin is a nephrotoxic immunosuppressant metabolized in the liver and requiring drug monitoring. Numerous pharmacokinetic and pharmacodynamic drug interactions have occurred with this compound. Some of them are well substantiated while others are merely suspected. The major interactions must definitely be prevented of corrected, whereas the others need no more than careful drug monitoring.
摘要
环孢素是一种具有肾毒性的免疫抑制剂，在肝脏中代谢，需要进行药物监测。该化合物已发生众多药代动力学和药效学药物相互作用。其中一些有充分证据，而另一些则只是怀疑。必须绝对预防或纠正主要的相互作用，而其他的则只需要仔细进行药物监测。
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