He J, Zeng Y L, Li W, Guo E E, Li J L, Kang Y, Shang J
Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou 450003, China.
Zhonghua Gan Zang Bing Za Zhi. 2017 Aug 20;25(8):618-622. doi: 10.3760/cma.j.issn.1007-3418.2017.08.012.
to compared with clinical data between nonalcoholic fatty liver disease (NAFLD) and Chronic HBV infection with NAFLD, and to explore the relationship between HBV infection and hepatic steatosis. A total of 81 patients with clinical data in the Department of Infectious Diseases in Henan Provincial People's Hospital from June 2013 to June 2016 were enrolled and divided into NAFLD group and HBV combined NAFLD group.Comparison of The levels of liver function (ALT, AST, ALP, GGT), blood lipid (TC, TG, HDL, LDL), blood glucose (GLU), uric acid (UA), hepatic fibrosis (S) and inflammation (G) And hepatic steatosis (F), and to explore the relationship between HBV infection and hepatic steatosis. The independent samples t-test or Wilcoxon two -sample test was used for comparison of continuous data,and the chi-square test was used for comparison of categorical data. Multinomial Logistic regression was used to analyze The risk factors of hepatic steatosis, < 0.05 was considered statistically significant. A total of 81 subjects were enrolled, with 31 in the NAFLD group and 36 in the HBV with NAFLD group. Baseline level comparison: ALT ( = -4.379, < 0.01)、AST ( = -3.847, < 0.01) 、GGT ( = -2.763, < 0.01) and F (χ(2) = 20.341, < 0.01), There were significant difference ( < 0.05); There were no significant differences in the levels of blood lipids, blood glucose, uric acid, inflammation and fibrosis. e antigen status of liver steatosis is a risk factor, hepatitis B viral load and liver steatosis has nothing to do. In addition to HBV infection-related indicators, it is difficult to distinguish between NAFLD and NAFLD combined with HBV differences; HBV infection and hepatic steatosis have a certain relationship.
比较非酒精性脂肪性肝病(NAFLD)与慢性HBV感染合并NAFLD的临床资料,探讨HBV感染与肝脂肪变性之间的关系。选取2013年6月至2016年6月在河南省人民医院感染科有临床资料的81例患者,分为NAFLD组和HBV合并NAFLD组。比较肝功能(ALT、AST、ALP、GGT)、血脂(TC、TG、HDL、LDL)、血糖(GLU)、尿酸(UA)、肝纤维化(S)、炎症(G)及肝脂肪变性(F)水平,探讨HBV感染与肝脂肪变性的关系。连续数据比较采用独立样本t检验或Wilcoxon两样本检验,分类数据比较采用卡方检验。采用多项Logistic回归分析肝脂肪变性的危险因素,P<0.05为差异有统计学意义。共纳入81例受试者,NAFLD组31例,HBV合并NAFLD组36例。基线水平比较:ALT(t=-4.379,P<0.01)、AST(t=-3.847,P<0.01)、GGT(t=-2.763,P<0.01)及F(χ²=20.341,P<0.01),差异有统计学意义(P<0.05);血脂、血糖、尿酸、炎症及纤维化水平差异无统计学意义。肝脂肪变性的e抗原状态是危险因素,乙肝病毒载量与肝脂肪变性无关。除HBV感染相关指标外,难以区分NAFLD与合并HBV的NAFLD的差异;HBV感染与肝脂肪变性有一定关系。