Ryan L J, Martone M E, Linder J C, Groves P M
Department of Psychiatry, University of California San Diego, La Jolla 92093-0603.
Brain Res Bull. 1988 Jul;21(1):133-7. doi: 10.1016/0361-9230(88)90129-3.
Continuous 3-day administration of d-amphetamine sulfate via a subcutaneous minipump induced the appearance of tyrosine hydroxylase immunoreactive patches in the neostriatum of adult Sprague-Dawley and Long-Evans rats at doses (greater than 20 mg/kg/day) that also produced axonal terminal degeneration as evidenced by Fink-Heimer silver grain deposition. The tyrosine hydroxylase patches coincided with striosomes identified by Leu-enkephalin immunoreactivity on adjacent sections. Sham-operated control, naive control, low dose amphetamine- (less than 15 mg/kg/day) and cocaine- (less than 125 mg/kg/day, IV) treated rats did not show tyrosine hydroxylase neostriatal patches nor axonal degeneration. These results suggest that the diffuse neostriatal dopamine system may be more susceptible to the neurotoxic, degenerative action of continuously administered amphetamine than is the islandic dopamine system.
通过皮下微型泵连续3天给予硫酸右苯丙胺，在成年Sprague-Dawley大鼠和Long-Evans大鼠的新纹状体中，当剂量大于20mg/kg/天时，会诱导出现酪氨酸羟化酶免疫反应性斑块，同时还会产生轴突终末变性，这可通过Fink-Heimer银粒沉积得以证明。酪氨酸羟化酶斑块与相邻切片上通过亮脑啡肽免疫反应性鉴定出的纹状体小体相重合。假手术对照组、未处理对照组、低剂量苯丙胺（小于15mg/kg/天）和可卡因（小于125mg/kg/天，静脉注射）处理的大鼠均未出现新纹状体酪氨酸羟化酶斑块，也未出现轴突变性。这些结果表明，弥漫性新纹状体多巴胺系统可能比岛状多巴胺系统更容易受到连续给予苯丙胺的神经毒性、退行性作用的影响。
