Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:3880-3883. doi: 10.1109/EMBC.2017.8037704.
This paper proposes a novel alignment-free sequence comparison method to identify the genetic relationships of organisms with a high resolution. For an accurate comparison, both frequency and position information of k-words are obtained from genome sequences in the proposed alignment-free sequence comparison method. Using principal component analysis (PCA) and phylogeny analysis, we identify the classification performance of proposed method. Then, the phylogenetic trees of proposed and conventional schemes are compared with reliable reference tree.
本文提出了一种新颖的无比对序列比较方法，以高分辨率识别生物体的遗传关系。在所提出的无比对序列比较方法中，从基因组序列中获取k-mer的频率和位置信息，以进行准确比较。利用主成分分析（PCA）和系统发育分析，我们确定了所提方法的分类性能。然后，将所提方案和传统方案的系统发育树与可靠的参考树进行比较。
