Patira Riddhi, Nathan Cody, Zubkov Sarah, Gutierrez Camilo, Munyon Charles, Mukherjee Abir, Jacobson Mercedes
Department of Neurology, Hospital of University of Pennsylvania, PA 19104, USA.
Department of Neurology, Temple University Hospital, Philadelphia, PA 19140, USA.
Epilepsy Behav Case Rep. 2017 Sep 12;8:92-95. doi: 10.1016/j.ebcr.2017.09.001. eCollection 2017.
Dysembryoplastic neuroepithelial tumor (DNET) is a benign brain tumor which commonly presents as childhood-onset temporal lobe epilepsy (TLE). We present a case of histologically proven DNET with a clinical presentation and scalp EEG suggestive of adult-onset TLE. MRI showed an occipital lesion. PET showed abnormal metabolism of the occipital lesion and the ipsilateral temporal lobe; raising concern for an abnormal functional network reorganization. Intracranial EEG showed interictal spikes and seizures originating from the occipital lesion with no seizures emanating from the temporal lobe. Occipital DNET due to their chronic nature can reorganize the network and mimic TLE.
胚胎发育不良性神经上皮肿瘤（DNET）是一种良性脑肿瘤，通常表现为儿童期起病的颞叶癫痫（TLE）。我们报告一例经组织学证实的DNET病例，其临床表现和头皮脑电图提示为成人起病的TLE。MRI显示枕叶有病变。PET显示枕叶病变及同侧颞叶代谢异常；这引发了对异常功能网络重组的担忧。颅内脑电图显示发作间期棘波和癫痫发作起源于枕叶病变，颞叶未出现癫痫发作。枕叶DNET因其慢性性质可使网络重组并模拟TLE。
