Effects of Multicide, Antibacterial Drug, on Staphylococcus Biomembranes.

作者信息

Tetz G V, Artemenko N K, Yankovskii G M, Kever L V, Komissarchik Ya Yu, Tetz V V

机构信息

Department of Microbiology and Virology, I. P. Pavlov St. Petersburg First State Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia.

MISiS National Research Technological Institute, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2017 Oct;163(6):780-784. doi: 10.1007/s10517-017-3902-z. Epub 2017 Oct 24.

DOI:10.1007/s10517-017-3902-z

PMID:29063334

Abstract

Drug penetration into bacterial biomembranes is one of the most important factors determining the efficiency of antibacterial therapy. Multicide, antibacterial drug, is a nanomolecule 1.3-2.0 nm in size, easily penetrating into staphylococcus biomembranes and causing rapid death of bacteria. The drug efficiency depends on its concentration and duration of exposure. Bacteria die as a result of cell wall perforation, which is associated with changes in its morphology and release of DNA from bacterial cell into the environment. Our results indicate the efficiency of primary damage to bacterial wall leading to elimination of biomembranes.

摘要