异丙嗪对大鼠心脏缺血及再灌注心律失常的影响。

Effects of promethazine on ischemic and reperfusion arrhythmias in rat heart.

作者信息

Rochette L, Yao-Kouame J, Bralet J, Opie L H

机构信息

Laboratoire de Pharmacodynamie et Physiologie Pharmaceutique, Université de Dijon, France.

出版信息

Fundam Clin Pharmacol. 1988;2(5):385-97. doi: 10.1111/j.1472-8206.1988.tb01004.x.

DOI:10.1111/j.1472-8206.1988.tb01004.x

PMID:2906896

Abstract

The effects of the H1-receptor antagonists promethazine, mepyramine, and chlorpheniramine on ischemic and reperfusion arrhythmias were studied in the isolated perfused rat heart. Promethazine reduced both ischemic and reperfusion arrhythmias (2 x 10(-6)M-7.5 x 10(-6)M). Mepyramine and chlorpheniramine decreased these arrhythmias but at concentrations about 10 times higher. The H2-blockers cimetidine and ranitidine had no antiarrhythmic effect. Promethazine also: (i) increased release of noradrenaline by the heart; and (ii) increased coronary flow in the reperfusion period and in some mildly ischemic zones. It is proposed that promethazine exerts most of its antiarrhythmic effects by a nonspecific mechanism, possibly membrane stabilization; in addition, enhanced coronary flow may play a role.

摘要

在离体灌注大鼠心脏中研究了H1受体拮抗剂异丙嗪、美吡拉敏和氯苯那敏对缺血性和再灌注性心律失常的影响。异丙嗪可减少缺血性和再灌注性心律失常（2×10⁻⁶M - 7.5×10⁻⁶M）。美吡拉敏和氯苯那敏可减少这些心律失常，但所需浓度约高10倍。H2受体阻滞剂西咪替丁和雷尼替丁没有抗心律失常作用。异丙嗪还：（i）增加心脏去甲肾上腺素的释放；（ii）在再灌注期以及一些轻度缺血区域增加冠脉血流量。有人提出，异丙嗪主要通过非特异性机制发挥其抗心律失常作用，可能是膜稳定作用；此外，冠脉血流量增加可能也起一定作用。