Ye Hai-Hui, Huang Hong-Hai, Wang Xiao-Lin, Pi You-Jun
Department of Blood Transfusion, Central Hospital of Xiangyang, Xiangyang 441021, Hubei Province, China.
Department of Blood Transfusion, Central Hospital of Xiangyang, Xiangyang 441021, Hubei Province, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Oct;25(5):1532-1536. doi: 10.7534/j.issn.1009-2137.2017.05.045.
To study the relationship between IgG titer of pregnant women and hemolytic disease of newborn(HDN) with different blood groups.
Four hundred pregnant women, including pregnant women with type O blood, were selected from May 2014 to January 2015 in our hospital for inspection and a couple of different blood groups, the IgG titer of pregnant women were detected in the inspection process. According to neonatal HDN, newborns were divided into 2 groups: HDN group(85 cases) and non-HDN group(315 cases). The incidence of postpartum neonatal hemolytic disease was tracked and the correlation of IgG titers with HDN were systematically analyzed.
In the production and inspection process, the IgG titer in pregnant women was divided into <1:64, 1:64, 1:128, 1:256 and greater than or equal to 1:512 five groups. the comparison of HDN incidence rate in 4 groups of IgG titer >64 and IgG titer <1:64 group showed that the prevalence of ABO hemolytic disease of newborn were 96.9%, 79.6%, 63, 7% and 28.8%, there was a certain correlation of pregnant women IgG titers with ABO hemolytic disease of the newborn, that is, with the increase of IgG titer, the incidence of hemolytic disease of newborns increased in certain degree (r=0.8832), the risk in 4 groups of neonatal HDN was higher than that in IgG titer <1:64 of IgG titer >64 HDN group.
There is a certain corelation between prevalence of ABO-HDN and IgG titer of pregnant women. For these pregnant women, the control of the pregnant women IgG titer has a positive clinical significance to reduce the incidence of hemolytic disease of the newborn.
研究孕妇IgG抗体效价与不同血型新生儿溶血病（HDN）之间的关系。
选取2014年5月至2015年1月我院收治的包括O型血孕妇在内的400例孕妇进行检查，检测孕妇及其配偶不同血型，在检查过程中检测孕妇的IgG抗体效价。根据新生儿HDN情况，将新生儿分为2组：HDN组（85例）和非HDN组（315例）。追踪产后新生儿溶血病的发病率，并系统分析IgG抗体效价与HDN的相关性。
在生产及检查过程中，将孕妇IgG抗体效价分为<1:64、1:64、1:128、1:256及≥1:512五组。IgG抗体效价>64的4组与IgG抗体效价<1:64组HDN发病率比较显示，新生儿ABO溶血病患病率分别为96.9%、79.6%、63.7%和28.8%，孕妇IgG抗体效价与新生儿ABO溶血病有一定相关性，即随着IgG抗体效价升高，新生儿溶血病发病率有一定程度升高（r=0.8832），IgG抗体效价>64的4组新生儿HDN风险高于IgG抗体效价<1:64组。
ABO-HDN患病率与孕妇IgG抗体效价之间存在一定相关性。对于此类孕妇，控制孕妇IgG抗体效价对于降低新生儿溶血病发病率具有积极的临床意义。
