Prakobwong Suksanti, Suwannatrai Apiporn, Sancomerang Achara, Chaipibool Suwit, Siriwechtumrong Ngampis
Department of Biology, Faculty of Science, Udon Thani Rajabhat University, Udon Thani, Thailand
Northeast Liver Fluke Research and Outreach Unit, Faculty of Science, Udon Thani Rajabhat University, Udon Thani, Thailand. Email:
Asian Pac J Cancer Prev. 2017 Oct 26;18(10):2853-2860. doi: 10.22034/APJCP.2017.18.10.2853.
Opisthorchis viverrini infection and cholangiocarcinoma are serious problems in South East Asia. This study aimed to find the prevalence of opisthorchiasis in various hosts in Udon Thani Province. Total fecal samples were collected from 14,766 participants. The epidemiological data collected and analysed included prevalence and intensity of infection. Odds ratios (OR) were calculated to determine the associations between cross sectional data and to predict possible risk factors. The prevalence of O. viverrini infection in Udon Thani Province averaged 15.3% (eggs per gram (epg.) = 48.9 and range; 12-1, 320), with differences between villages (range; 3.8%-79.8%). An age-dependence for infection was observed to increase from ages 25 to 50 years and then decrease for older participants. A univariate analysis identified risk parameters including age (p = 0.040; OR = 3.9 (95% CI = 1.2-7.5)), education (p < 0.0001; OR = 7.3 (95% CI = 1.8-21.6)) and eating habits (p = 0.032; OR = 1.6 (95% C = 0.5-3.7)). Interestingly, most participants were not aware of treatments such as praziquantel (p < 0.0001; OR = 3.5 (95% CI = 1.4-11.6)), had no history of parasitic treatment (p = 0.486; OR = 1.5 (95% CI = 0.5-3.5) and had eaten raw fish (p=0.04; OR = 7.4 (95% CI = 1.5-18.6)). Liver fluke infection in dogs (18.1%, epg. = 44.7, range; 32-96) was significantly higher than in cats (11.0%, epg. = 117.8, range; 44-372) (p < 0.05). A positive association between O. viverrini infection in dogs and their owners was found. In addition, cyprinid fish dominantly infected by metacercaria including Henicorhynchus siamensis (27.7%), Cyclocheilichthys repasson (21.9%), Hampala dispar (14.1%), and Barbonymus gonionotus (6.9%). This study provides basic information required for the development of future effective and sustainable strategies to reduces infection rates, mainly by providing health education and encouraging behavioural changes.
华支睾吸虫感染和胆管癌是东南亚地区的严重问题。本研究旨在查明乌隆他尼府不同宿主中华支睾吸虫病的流行情况。共收集了14766名参与者的粪便样本。所收集和分析的流行病学数据包括感染率和感染强度。计算优势比（OR）以确定横断面数据之间的关联并预测可能的风险因素。乌隆他尼府华支睾吸虫感染率平均为15.3%（每克虫卵数（epg.）=48.9，范围为12 - 1320），不同村庄之间存在差异（范围为3.8% - 79.8%）。观察到感染呈现年龄依赖性，在25至50岁之间上升，然后在年龄较大的参与者中下降。单因素分析确定的风险参数包括年龄（p = 0.040；OR = 3.9（95%置信区间 = 1.2 - 7.5））、教育程度（p < 0.0001；OR = 7.3（95%置信区间 = 1.8 - 21.6））和饮食习惯（p = 0.032；OR = 1.6（95%置信区间 = 0.5 - 3.7））。有趣的是，大多数参与者不知道诸如吡喹酮之类的治疗方法（p < 0.0001；OR = 3.5（95%置信区间 = 1.4 - 11.6）），没有寄生虫治疗史（p = 0.486；OR = 1.5（95%置信区间 = 0.5 - 3.5））并且食用过生鱼（p = 0.04；OR = 7.4（95%置信区间 = 1.5 - 18.6））。犬类肝吸虫感染率（18.1%，epg. = 44.7，范围为32 - 96）显著高于猫类（11.0%，epg. = 117.8，范围为44 - 372）（p < 0.05）。发现犬类与其主人的华支睾吸虫感染之间存在正相关。此外，主要被后尾蚴感染的鲤科鱼类包括暹罗野结鱼（27.7%）、似野结鱼（21.9%）、高体波鱼（14.1%）和断线鲃（6.9%）。本研究提供了未来制定有效且可持续策略以降低感染率所需的基础信息，主要是通过提供健康教育和鼓励行为改变来实现。
