Université de Lyon, Centre National de la Recherche Scientifique, Institut des Sciences Cognitives Marc Jeannerod, Bron, France.
Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Lyon, France.
Mov Disord. 2018 Feb;33(2):298-309. doi: 10.1002/mds.27201. Epub 2017 Oct 27.
Diffusion tensor imaging has received major interest to highlight markers of neurodegeneration in Parkinson's disease. Whether the alteration of diffusion parameters mostly depicts dopaminergic lesions or can also reveal serotonergic denervation remains a question.
The aim of this study was to determine the best diffusion tensor imaging markers of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 3,4-methylene-dioxy-methamphetamine (MDMA; also known as ecstasy) lesions in the nonhuman primate.
We acquired measures of mean diffusivity and fractional anisotropy longitudinally (before and after MPTP and MDMA) and correlated them with severity of parkinsonism, PET imaging, and postmortem fiber quantification.
MPTP-induced lesions were associated with increases of mean diffusivity within both the caudate nucleus and the anterior cingulate cortex, whereas MDMA-induced lesions caused an increase of fractional anisotropy within the caudate nucleus. These variations of diffusion tensor imaging correlated with the motor score.
Taken together, these results demonstrate that diffusion measures within specific brain regions can mark severity of dopaminergic and serotonergic induced lesions in a neurotoxic nonhuman primate model of Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society.
弥散张量成像已受到广泛关注，用于突出帕金森病神经退行性变的标志物。弥散参数的改变主要描述多巴胺能病变，还是也能显示 5-羟色胺能神经支配丧失，这仍然是一个问题。
本研究旨在确定 1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）和 3,4-亚甲二氧基甲基苯丙胺（MDMA；也称为摇头丸）在非人灵长类动物中的病变的最佳弥散张量成像标志物。
我们纵向（MPTP 和 MDMA 之前和之后）获得了平均弥散度和各向异性分数的测量值，并将其与帕金森病的严重程度、PET 成像和死后纤维定量相关联。
MPTP 诱导的病变与尾状核和前扣带回内的平均弥散度增加有关，而 MDMA 诱导的病变导致尾状核内的各向异性分数增加。这些弥散张量成像的变化与运动评分相关。
总之，这些结果表明，在帕金森病的神经毒性非人灵长类动物模型中，特定脑区的弥散测量值可以标记多巴胺能和 5-羟色胺能诱导病变的严重程度。 © 2017 国际帕金森病和运动障碍协会。
