胰岛素样生长因子 II 信使 RNA 结合蛋白 3 是子宫平滑肌肉瘤的独立预后因素。
Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma.
机构信息
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Pathology, National Kyushu Cancer Center, Fukuoka, Japan.
出版信息
Histopathology. 2018 Apr;72(5):739-748. doi: 10.1111/his.13422. Epub 2018 Jan 5.
AIMS
The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma (ULMS).
METHODS AND RESULTS
We reviewed 60 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expression of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (P < 0.0001), older age (P = 0.0244) and IMP3 expression (P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (P < 0.0001) and IMP3 (P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study.
CONCLUSIONS
IMP3 expression in ULMS could be a marker of a poor prognosis.
目的
本研究旨在确定子宫平滑肌肉瘤（ULMS）的预后因素。
方法和结果
我们回顾了 60 例手术切除的 ULMS，并通过免疫组织化学方法研究了常规临床病理因素以及胰岛素样生长因子 II 信使 RNA 结合蛋白 3（IMP3）、激素受体和细胞周期调节标志物的表达。还进行了中介复合物亚基 12（MED12）突变分析。单因素分析显示，晚期（P < 0.0001）、年龄较大（P = 0.0244）和 IMP3 表达（P = 0.0011）是不良预后的显著预测因素。多因素分析显示，晚期（P < 0.0001）和 IMP3（P = 0.0373）是不良预后的独立预测因素。在本研究中，细胞周期标志物和激素受体的表达以及 MED12 突变（ULMS 中为 12%）并未被确定为预后标志物。
结论
ULMS 中 IMP3 的表达可能是预后不良的标志物。
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