实验性胰岛异种移植在糖尿病非人灵长类动物模型中无需免疫抑制即可获得良好结果。
Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.
机构信息
Department of Medicine III, University Hospital Carl Gustav Carus, Dresden D-01307, Germany;
Paul Langerhans Institute Dresden of the Helmholtz Center Munich at The University Hospital Carl Gustav Carus and Faculty of Medicine of the TU Dresden, Dresden D-01307, Germany.
出版信息
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11745-11750. doi: 10.1073/pnas.1708420114. Epub 2017 Oct 16.
Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.
胰岛细胞移植治疗 1 型糖尿病受到限制，因为需要免疫抑制和供体器官短缺，这会导致患者代谢不稳定。为了克服这些障碍，我们开发了一种策略，将来自不同来源的胰岛进行宏观封装，使其在无需免疫抑制的情况下存活和发挥功能。在这里，我们报告了在没有任何免疫抑制的情况下，使用生物人工胰腺设备成功安全地移植猪胰岛细胞于糖尿病灵长类动物。该策略有望引领针对糖尿病的异种移植的开创性临床试验，从而为广泛的内分泌紊乱和其他器官功能障碍提供有效的细胞替代方法。
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