[重型再生障碍性贫血异基因造血干细胞移植后移植物功能不良的危险因素分析]
[Risk-factor analysis of poor graft function after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia].
作者信息
Shi C Y, Mamal Z H, Liu X X, Wu L H, Xia D N, Nie Y R, Lai F Q, Duan H W, Xiao Z J, Jiang Y H, Li Y, Xiao Yang
机构信息
Department of Hematology, General Hospital of Guangzhou Military Command of PLA, Southern Medical University, Guangzhou 510015, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2017 Sep 14;38(9):761-766. doi: 10.3760/cma.j.issn.0253-2727.2017.09.006.
To investigate the risk factors of poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia (SAA) . Clinical data from 111 SAA patients who received allo-HSCT were analyzed retrospectively. Factors including age, gender, interval to transplantation, the level of serum ferritin before transplantation were analyzed by Cox multivariate regression analysis. Among the 111 patients who underwent allo-HSCT, 16 developed PGF (14.4%) . Multivariate analysis showed donor type (=2.656, 95% 1.204-5.858, = 0.016) and the level of serum ferritin before tansplantation (=3.170, 95% 1.400-7.180, =0.006) were significant risk factors for PGF. Unrelated donor transplantation and the high level of serum ferritin before transplantation are risk factors for PGF.
探讨重型再生障碍性贫血（SAA）患者接受异基因造血干细胞移植（allo-HSCT）后移植功能不良（PGF）的危险因素。回顾性分析111例接受allo-HSCT的SAA患者的临床资料。采用Cox多因素回归分析年龄、性别、移植间隔时间、移植前血清铁蛋白水平等因素。在111例行allo-HSCT的患者中，16例发生PGF（14.4%）。多因素分析显示供者类型（=2.656，95%可信区间1.204-5.858，=0.016）和移植前血清铁蛋白水平（=3.170，95%可信区间1.400-7.180，=0.006）是PGF的显著危险因素。无关供者移植和移植前血清铁蛋白水平高是PGF的危险因素。
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