Razi Hospital, Tehran University of Medical Science, Tehran, Iran.
Center for Research & Training in Skin Disease & Leprosy, Tehran University of Medical Science, Tehran, Iran.
Dermatol Ther. 2018 Jan;31(1). doi: 10.1111/dth.12564. Epub 2017 Oct 30.
The effect of thermotherapy in the treatment of skin warts in comparison to cryotherapy, as the standard conventional method, has remained uncertain. This study aimed to assess the clinical efficacy and safety of thermotherapy and cryotherapy in removing skin warts. This randomized controlled trial was conducted on 52 patients aged 18 years and over with ≤ 10 skin warts. The participants were randomly assigned into two groups to receive cryotherapy (every 2 to 3 weeks up to six sessions if required) or thermotherapy (one session). The patients in both groups were followed every 2 to 3 weeks for the first three months, and then three months after the last treatment session. The clearance rate was 79.2% in the thermotherapy group and 58.3% in the cryotherapy group with no significant difference (p = 0.212). The rate of scarring in the thermotherapy group was 20% (p = .018). A higher clearance rate was achieved in the thermotherapy group. However, this result was not statistically significant. There were some minimal post-treatment complications. Patients needed only one session of thermotherapy. Due to the risk of scarring, we suggest thermotherapy only as a suitable treatment method for palmoplantar warts.
热疗治疗皮肤疣与冷冻疗法（作为标准常规方法）的效果仍不确定。本研究旨在评估热疗和冷冻疗法去除皮肤疣的临床疗效和安全性。这是一项随机对照试验，共纳入 52 名年龄在 18 岁及以上、皮肤疣数≤10 的患者。参与者被随机分为两组，分别接受冷冻疗法（每 2-3 周进行一次，最多 6 次，如果需要）或热疗（一次）。两组患者在前 3 个月每 2-3 周随访一次，然后在最后一次治疗后 3 个月随访一次。热疗组的清除率为 79.2%，冷冻组为 58.3%，差异无统计学意义（p=0.212）。热疗组的瘢痕形成率为 20%（p=0.018）。热疗组的清除率较高。然而，这一结果没有统计学意义。治疗后有一些轻微的并发症。患者只需接受一次热疗。由于存在瘢痕形成的风险，我们建议仅将热疗作为掌跖疣的一种合适治疗方法。
