Numano F, Matsumoto H, Miyazaki T, Kawai N
Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Exp Clin Immunogenet. 1986;3(1):20-7.
As HLA studies suggest that the genetic factors contributing to the pathogenesis of Takayasu disease may be polygene, various red blood types, allotypes of serum protein and red blood cell enzyme polymorphisms in eighty-four patients with Takayasu disease were studied and their phenotypes and gene frequencies were compared with those in healthy Japanese. Statistically significant high frequencies of phenotypes and/or gene frequencies were confirmed in MNSs, Rh-Hr, Tf, Gc and Pi in Takayasu disease, as compared with those in controls. These characteristics of gene frequencies were more remarkable in patients who do not carry HLA Bw52. These data suggest that the genetic factors contributing to the pathogenesis of Takayasu disease are polygene and may be located in chromosome No. 1, 4 and 14.
由于 HLA 研究表明，导致大动脉炎发病机制的遗传因素可能是多基因的，因此对 84 例大动脉炎患者的各种血型、血清蛋白同种异型和红细胞酶多态性进行了研究，并将其表型和基因频率与健康日本人进行了比较。与对照组相比，大动脉炎患者在 MNSs、Rh-Hr、Tf、Gc 和 Pi 中表型和/或基因频率具有统计学意义的高频率。这些基因频率特征在不携带 HLA Bw52 的患者中更为显著。这些数据表明，导致大动脉炎发病机制的遗传因素是多基因的，可能位于第 1、4 和 14 号染色体上。
