合成原细胞群落中的基因介导化学通讯。
Gene-Mediated Chemical Communication in Synthetic Protocell Communities.
作者信息
Tang T-Y Dora, Cecchi Dario, Fracasso Giorgio, Accardi Davide, Coutable-Pennarun Angelique, Mansy Sheref S, Perriman Adam W, Anderson J L Ross, Mann Stephen
机构信息
Max Planck Institute of Molecular Cell and Genetics , 01307 Dresden, Germany.
BrisSynBio Synthetic Biology Research Centre, Life Sciences Building, University of Bristol , Tyndall Avenue, Bristol BS8 1TQ, U.K.
出版信息
ACS Synth Biol. 2018 Feb 16;7(2):339-346. doi: 10.1021/acssynbio.7b00306. Epub 2017 Nov 8.
A gene-directed chemical communication pathway between synthetic protocell signaling transmitters (lipid vesicles) and receivers (proteinosomes) was designed, built and tested using a bottom-up modular approach comprising small molecule transcriptional control, cell-free gene expression, porin-directed efflux, substrate signaling, and enzyme cascade-mediated processing.
利用一种自下而上的模块化方法，设计、构建并测试了一条在合成原细胞信号发射器（脂质囊泡）和接收器（蛋白质体）之间由基因指导的化学通讯途径，该方法包括小分子转录控制、无细胞基因表达、孔蛋白导向的外排、底物信号传导以及酶级联介导的加工过程。
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