Gaikwad Manasi, Vanlint Simon, Moseley G Lorimer, Mittinty Murthy N, Stocks Nigel
a Discipline of General Practice, School of Medicine , University of Adelaide , Adelaide , SA , Australia.
b Sansom Institute for Health Research , University of South Australia , Adelaide , SA , Australia.
J Diet Suppl. 2018 Sep 3;15(5):636-648. doi: 10.1080/19390211.2017.1375060. Epub 2017 Nov 2.
Vitamin D deficiency is a public health issue, with reports of six- to twenty-five-fold rise in vitamin D testing. Vitamin D deficiency has been linked to many chronic diseases such as diabetes mellitus, cardiovascular disease, depression, and chronic pain. Identifying factors associated with risk of deficiency in individuals with chronic pain will help minimize time and cost. This study aims to examine the factors associated with vitamin D testing, intake, and physician-advised supplementation in individuals with chronic pain. Using a cross-sectional design, data were collected from 465 individuals with chronic pain. These data were analyzed using penalized logistic regression with the LASSO technique. Fifty-seven percent reported being tested for vitamin D, about 40% reported being diagnosed with vitamin D deficiency, and of those who had been tested, 60% reported taking vitamin D supplementation. The findings suggest older age (OR 3.12, CI [1.02, 9.50]) and higher mean pain intensity score (OR 2.02, CI [1.13, 3.59]) increased an individual's chance of being vitamin D deficient. Unemployment or on leave due to pain (OR 1.79, [CI 1.03, 3.11]), part-time employment (OR 1.86, CI [1.02, 3.39]), and being a resident of Australia (OR 2.32, CI [1.13, 4.72]) increased chances of being tested for vitamin D. Being diagnosed with vitamin D deficiency (OR 6.67, CI [2.75, 16.19]), unemployed or on leave due to pain (OR 3.71, CI [1.25, 11.00]), and in part-time employment (OR 2.69, CI [0.86, 8.38]) were associated with physician-advised vitamin D supplementation. Our results may have practical implications, as identifying pretest risk factors may assist in identifying who is at risk of vitamin D deficiency, whom to test, and when to treat.
维生素D缺乏是一个公共卫生问题，维生素D检测报告显示其增长了6至25倍。维生素D缺乏与许多慢性疾病有关，如糖尿病、心血管疾病、抑郁症和慢性疼痛。确定慢性疼痛患者中与维生素D缺乏风险相关的因素将有助于减少时间和成本。本研究旨在探讨慢性疼痛患者中与维生素D检测、摄入量以及医生建议补充维生素D相关的因素。采用横断面设计，收集了465名慢性疼痛患者的数据。使用LASSO技术的惩罚逻辑回归分析这些数据。57%的人报告进行了维生素D检测，约40%的人报告被诊断为维生素D缺乏，在接受检测的人中，60%的人报告正在补充维生素D。研究结果表明，年龄较大（OR 3.12，CI [1.02, 9.50]）和平均疼痛强度评分较高（OR 2.02，CI [1.13, 3.59]）会增加个体维生素D缺乏的几率。因疼痛失业或休假（OR 1.79，[CI 1.03, 3.11]）、兼职工作（OR 1.86，CI [1.02, 3.39]）以及居住在澳大利亚（OR 2.32，CI [1.13, 4.72]）会增加进行维生素D检测的几率。被诊断为维生素D缺乏（OR 6.67，CI [2.75, 16.19]）、因疼痛失业或休假（OR 3.71，CI [1.25, 11.00]）以及从事兼职工作（OR 2.69，CI [0.86, 8.38]）与医生建议补充维生素D有关。我们的研究结果可能具有实际意义，因为识别检测前的风险因素可能有助于确定谁有维生素D缺乏风险、检测对象以及何时进行治疗。
