患发作性睡病综合征的同卵双胞胎。

Monozygotic twins concordant for the narcoleptic syndrome.

作者信息

Douglass A B, Harris L, Pazderka F

机构信息

Faculty of Medicine, University of Alberta, Edmonton, Canada.

出版信息

Neurology. 1989 Jan;39(1):140-1. doi: 10.1212/wnl.39.1.140.

DOI:10.1212/wnl.39.1.140

PMID:2909903

Abstract

We report the first documented monozygotic twins who both had the narcoleptic syndrome. We assessed monozygosity by HLA antigens and by blood groups. In contrast to virtually all other narcoleptics, they had HLA-DQ1 instead of HLA-DR2; this helped to localize the gene, and perhaps explains its greater expressivity in these than in other twins.

摘要

我们报告了首例有发作性睡病综合征的同卵双胞胎病例记录。我们通过HLA抗原和血型评估了同卵性。与几乎所有其他发作性睡病患者不同，他们拥有HLA-DQ1而非HLA-DR2；这有助于确定该基因的位置，并且或许可以解释该基因在这对双胞胎中比在其他双胞胎中具有更高的表达性。