Strichartz S D, Abedin M Z, Safarian E K, Roslyn J J
Department of Surgical and Research Services, Sepulveda Veterans Administration Medical Center, California.
Am J Surg. 1989 Jan;157(1):163-7. doi: 10.1016/0002-9610(89)90440-6.
Feeding corn and alfalfa to young prairie dogs resulted in formation of gallstones composed of 45 percent cholesterol, 30 percent bile pigments, and 25 percent calcium bilirubinate in half of the animals. This diet also resulted in increased gallbladder bile concentrations of calcium, phospholipids, and cholesterol. Although the cholesterol saturation index was significantly increased compared with control subjects, it remained less than 1. In addition to the changes in biliary lipid composition, the corn and alfalfa-fed animals had significantly decreased transepithelial potential difference and short-circuit current when compared with control animals. These are changes in gallbladder mucosal function similar to those that have been reported in humans with gallstones. This model may therefore prove to be of great value in studying the pathogenesis of noncholesterol gallstones.
给幼年草原犬喂食玉米和苜蓿后，半数动物形成了胆结石，其组成成分包括45%的胆固醇、30%的胆色素和25%的胆红素钙。这种饮食还导致胆囊胆汁中钙、磷脂和胆固醇的浓度升高。尽管与对照组相比，胆固醇饱和指数显著升高，但仍低于1。除了胆汁脂质成分的变化外，与对照动物相比，喂食玉米和苜蓿的动物跨上皮电位差和短路电流显著降低。这些胆囊黏膜功能的变化与人类胆结石患者所报道的变化相似。因此，该模型可能在研究非胆固醇胆结石的发病机制方面具有重要价值。
