Brzozowska Maria, Bieniek Ewa, Szosland Konrad, Lewinski Andrzej
Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital and Research Institute, Lodz, Poland.
Neuro Endocrinol Lett. 2017 Oct;38(5):311-315.
Gestational diabetes (GDM) is a relatively common complication of pregnancy. Maternal hyperglycemia causes many serious side effects for mothers, fetuses and newborns. In 90% of women diagnosed with GDM, a dietary treatment results in satisfactory levels of blood glucose. The remaining 10% require insulin therapy to achieve the recommended glycemic levels. The majority of recent studies show the efficiency of metformin in gestational diabetes and prove that it is not a cause for any harmful side effects to the embryo and/or fetus. Metformin is an effective alternative to insulin in glycemic control in pregnant women. The implementation of metformin, as a routine procedure in gestational diabetes, requires further research, the results of which would unequivocally confirm its efficacy and safety for pregnant women and their offspring.
妊娠期糖尿病（GDM）是一种相对常见的妊娠并发症。母体高血糖会给母亲、胎儿和新生儿带来许多严重的副作用。在90%被诊断为GDM的女性中，饮食治疗可使血糖水平达到满意状态。其余10%的患者需要胰岛素治疗以达到推荐的血糖水平。最近的大多数研究表明二甲双胍对妊娠期糖尿病有效，并证明它不会对胚胎和/或胎儿造成任何有害副作用。在控制孕妇血糖方面，二甲双胍是胰岛素的有效替代品。将二甲双胍作为妊娠期糖尿病的常规治疗方法，还需要进一步研究，其结果将明确证实其对孕妇及其后代的有效性和安全性。
