Garg Anjali, Kumari Bandana, Kumar Ravindra, Kumar Manish
Department of Biophysics, University of Delhi, New Delhi, India.
Front Microbiol. 2017 Oct 23;8:2053. doi: 10.3389/fmicb.2017.02053. eCollection 2017.
Autoimmune diseases emerge due to several reasons, of which molecular mimicry i.e., similarity between the host's and pathogen's interacting peptides is an important reason. In the present study we have reported a database of only experimentally verified peptide sequences, which exhibit molecular mimicry. The database is named as micry tide Data) and contains comprehensive information about mimicry proteins and peptides of both host (and model organism) and pathogen. It also provides information about physicochemical properties of protein and mimicry peptides, which might be helpful in predicting the nature of protein and optimization of protein expression. The can be searched using a keyword or, by autoimmune disease(s) or by a combination of host and pathogen taxonomic group or their name. To facilitate the search of proteins and/or epitope in miPepBase, which is similar to the user's interest, BLAST search tool is also incorporated. is an open access database and available at http://proteininformatics.org/mkumar/mipepbase.
自身免疫性疾病的出现有多种原因,其中分子模拟,即宿主与病原体相互作用肽之间的相似性是一个重要原因。在本研究中,我们报告了一个仅包含经实验验证的表现出分子模拟的肽序列的数据库。该数据库名为micry tide Data,包含有关宿主(和模式生物)以及病原体的模拟蛋白和肽的全面信息。它还提供了有关蛋白质和模拟肽的物理化学性质的信息,这可能有助于预测蛋白质的性质和优化蛋白质表达。可以使用关键词、按自身免疫性疾病或按宿主和病原体分类群或其名称的组合进行搜索。为便于在与用户兴趣相似的miPepBase中搜索蛋白质和/或表位,还纳入了BLAST搜索工具。miPepBase是一个开放获取的数据库,可在http://proteininformatics.org/mkumar/mipepbase上获取。