Gu Dongfeng, Ding Yanan, Zhao Yunfeng, Qu Qingshan
Department of Nephrology and Transplantation Center, The People's Hospital of Zhengzhou, Affiliated with Southern Medical University, Zhengzhou 450003, P.R. China.
Division of Cardiovascular Medicine, The People's Hospital of Zhengzhou, Affiliated with Southern Medical University, Zhengzhou 450003, P.R. China.
Exp Clin Endocrinol Diabetes. 2018 Nov;126(10):596-603. doi: 10.1055/s-0043-120440. Epub 2017 Nov 8.
To study the relationship of visceral adiposity index (VAI) and prediabetes and the power of which in predicting of prediabetes.
A cross-sectional epidemiological survey was conducted. All participants were divided into four groups: VAI and WC (both are normal), VAI↑ and WC (postcritical VAI and normal WC), VAI and WC↑ (Normal VAI and postcritical WC), and VAI↑ and WC↑ (postcritical VAI and postcritical WC). A multivariate logistic analysis was used to analyze the relationship between the four groups and prediabetes, and diabetes. A receiver operating characteristic (ROC) curve analysis was used to evaluate the accuracy of predictions for prediabetes and diabetes.
Both VAI and WC were independent risk factors of Prediabetes. The ORs for Prediabetes in the VAI↑&WC group were 1.641 (95%CI 1.146-2.349), P=0.007, in males, in Model 2. The ORs for Prediabetes in the VAI&WC↑ group were 1.454 (95%CI 1.055-2.005), P=0.022, in males, in Model 2. The ORs for Prediabetes in the VAI↑&WC group were 2.305 (95%CI 1.623-3.273), P=0.000, in females, in Model 2. The ORs for Prediabetes in the VAI&WC↑ group were 1.997 (95%CI 1.529-2.608), P=0.000, in females, in Model 2. The AUC value of VAI were 0.601 (95%CI 0.568-0.634), P=0.000, in prediabetes of men; which were 0.645 (95%CI 0.618-0.672), P=0.000, in prediabetes women. WC had the highest AUC value of 0.605 (95%CI 0.571-0.638), P=0.000, in prediabetes of men, also had the highest of AUC value of 0.673 (95%CI 0.648-0.697), P=0.000, in prediabetes of women.
VAI was positively associated with prediabetes, and also a usefulindicator of prediabetes.
研究内脏脂肪指数(VAI)与糖尿病前期的关系及其预测糖尿病前期的效能。
进行一项横断面流行病学调查。所有参与者被分为四组:VAI和腰围(WC)均正常、VAI升高且WC正常(VAI临界值以上且WC正常)、VAI正常且WC升高(VAI正常且WC临界值以上)、VAI升高且WC升高(VAI临界值以上且WC临界值以上)。采用多因素逻辑回归分析四组与糖尿病前期及糖尿病之间的关系。采用受试者工作特征(ROC)曲线分析评估糖尿病前期和糖尿病预测的准确性。
VAI和WC均为糖尿病前期的独立危险因素。在模型2中,男性VAI升高且WC正常组糖尿病前期的比值比(OR)为1.641(95%可信区间1.146 - 2.349),P = 0.007。男性VAI正常且WC升高组糖尿病前期的OR为1.454(95%可信区间1.055 - 2.005),P = 0.022。女性VAI升高且WC正常组糖尿病前期的OR为2.305(95%可信区间1.623 - 3.273),P = 0.000。女性VAI正常且WC升高组糖尿病前期的OR为1.997(95%可信区间1.529 - 2.608),P = 0.000。男性糖尿病前期中VAI的曲线下面积(AUC)值为0.601(95%可信区间0.568 - 0.634),P = 0.000;女性糖尿病前期中VAI的AUC值为0.645(95%可信区间0.618 - 0.672),P = 0.000。男性糖尿病前期中WC的AUC值最高,为0.605(95%可信区间0.571 - 0.638),P = 0.000;女性糖尿病前期中WC的AUC值也最高,为0.673(95%可信区间0.648 - 0.697),P = 0.000。
VAI与糖尿病前期呈正相关,也是糖尿病前期的一个有用指标。