警惕帕金森病中的痴呆症。

Be vigilant for dementia in Parkinson’s disease.

作者信息

Niccolini Flavia, Diamantopoulos Konstantinos, Kiosses Stelios, Politis Marios

出版信息

Practitioner. 2017 May;261(1804):11-5.

DOI:
Abstract

It is estimated that up to 80% of patients with Parkinson's disease will eventually develop cognitive impairment over the course of their illness. Even at the time of diagnosis, cognitive impairment has been reported in 20-25% of patients. Commonly affected cognitive domains are executive function, visuospatial ability and attention control. In addition, patients with Parkinson's disease dementia may present with deficits in language function and verbal memory. Psychosis may occur in approximately 40% of patients with Parkinson's disease, and is associated with an increased risk of developing cognitive impairment. Studies have shown that patients with Parkinson's disease with a history of visual hallucinations had an increased risk of developing dementia, four to eight years following diagnosis of the disease. Other clinical risk factors associated with cognitive decline in patients with Parkinson's disease include older age of onset, severe motor symptom burden and in particular akinetic-rigid subtype and olfactory dysfunction. Patients with Parkinson's disease who present with symptoms of cognitive decline, behavioural changes or psychotic symptoms should be referred for further investigation.

摘要

据估计,高达80%的帕金森病患者在病程中最终会出现认知障碍。即使在诊断时,也有20%-25%的患者被报告存在认知障碍。常见受影响的认知领域包括执行功能、视觉空间能力和注意力控制。此外,帕金森病痴呆患者可能会出现语言功能和言语记忆方面的缺陷。约40%的帕金森病患者可能会出现精神病症状,且与发生认知障碍的风险增加有关。研究表明,有视幻觉病史的帕金森病患者在疾病诊断后四至八年发生痴呆的风险增加。与帕金森病患者认知衰退相关的其他临床风险因素包括发病年龄较大、严重的运动症状负担,尤其是运动不能-强直亚型和嗅觉功能障碍。出现认知衰退、行为改变或精神病症状的帕金森病患者应转诊进行进一步检查。

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