瓜德罗普岛符合大规模乳腺癌筛查条件的患者侵袭性乳腺癌特征及总生存率与前一年龄组患者的比较。
Characteristics of invasive breast cancer and overall survival of patients eligible for mass breast cancer screening in Guadeloupe compared to those of the preceding age group.
作者信息
Kadhel Philippe, Borja De Mozota Daphné, Gaumond Stéphanie, Deloumeaux Jacqueline
机构信息
Service de Gynécologie-Obstétrique Centre Hospitalier Universitaire de Guadeloupe, Guadeloupe F.W.I. Route de Chauvel, 97159 Pointe-à-Pitre Cedex, France; Institut National de la Santé et de la Recherche Médicale Inserm U1085-IRSET, Campus Universitaire de Fouillole, Pointe à Pitre 97157, Guadeloupe, France.
Service de Gynécologie-Obstétrique Centre Hospitalier Universitaire de Guadeloupe, Guadeloupe F.W.I. Route de Chauvel, 97159 Pointe-à-Pitre Cedex, France.
出版信息
Cancer Epidemiol. 2017 Oct;50(Pt B):268-271. doi: 10.1016/j.canep.2017.08.004.
BACKGROUND
Mass breast cancer screening is offered to French women between the ages of 50 and 74. In the French overseas department of Guadeloupe, where the population is of mostly African ancestry, a low age at diagnosis of breast cancer has been reported, as for African-Americans. This raises the question of whether breast cancer is more aggressive in the age group preceding that eligible for mass screening (40-49) in Guadeloupe.
METHODS
We compared the tumor-related prognostic factors, first line therapy and overall survival rates of breast cancer cases diagnosed between the 40-49 and 50-74 age groups, based on reports of the cancer registry of Guadeloupe for the period 2008-2013.
RESULTS
The characteristics studied, risk of death after breast cancer (HR 0.84 [95% CI: 0.58-1.22] and overall survival, did not differ significantly between the two groups, except for higher tumor size (28.8 vs 24.0; p=0.004) in the younger group.
CONCLUSION
These results do not show a pattern of more aggressive breast cancer in the age group preceding that eligible for mass screening in Guadeloupe.
背景
法国为年龄在50至74岁之间的女性提供大规模乳腺癌筛查。在法属海外省瓜德罗普岛，其人口大多为非洲裔，据报道乳腺癌诊断年龄较低，与非裔美国人情况类似。这就提出了一个问题，即在瓜德罗普岛，在符合大规模筛查条件的年龄组（50 - 74岁）之前的年龄组（40 - 49岁）中，乳腺癌是否更具侵袭性。
方法
根据瓜德罗普岛癌症登记处2008 - 2013年期间的报告，我们比较了40 - 49岁和50 - 74岁年龄组中确诊的乳腺癌病例的肿瘤相关预后因素、一线治疗情况和总生存率。
结果
除较年轻组的肿瘤大小更大（28.8对24.0；p = 0.004）外，所研究的特征、乳腺癌死亡风险（HR 0.84 [95% CI：0.58 - 1.22]）和总生存率在两组之间没有显著差异。
结论
这些结果并未显示在瓜德罗普岛符合大规模筛查条件之前的年龄组中乳腺癌更具侵袭性的模式。
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