足月新生儿氧化应激与胎盘中脂质关联及其与延迟断脐的关系。
Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates.
机构信息
Department of Pediatrics, Minia University Hospital, Al-Minya, 61111, Egypt.
Department of Obstetrics and Gynecology, Minia University Hospital, Al-Minya, Egypt.
出版信息
Lipids Health Dis. 2017 Nov 9;16(1):210. doi: 10.1186/s12944-017-0599-y.
BACKGROUND
Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids.
METHODS
One-hundred mothers and their term neonates were included in the present study. Umbilical cord blood samples were collected from the umbilical vein and umbilical artery immediately following labor.
RESULTS
Total cholesterol, total triglycerides and phospholipids levels were significantly higher in the ECC group than the DCC group (p < 0.001 in all). Plasma total antioxidant status was higher in the DCC group than the ECC group (p < 0.001). While, plasma hydroperoxides were lower in the DCC group than the ECC group (p < 0.001). Levels of erythrocytes catalase cytosol, superoxide dismutase and glutathione peroxidase were significantly higher in the DCC group than the ECC group (p < 0.001).
CONCLUSION
DCC was associated with a decrease in cord blood lipids and an augmented antioxidant activity. This suggests the protective effect of DCC on the future health of the term neonates and supports the application of DCC in active management of 3rd stage of labor in term neonates.
背景
尽管延迟脐带夹闭（DCC）是世界卫生组织的最新建议，但在许多国家，早期脐带夹闭（ECC）仍然是常规做法。有限的研究研究了延迟脐带夹闭对足月新生儿氧化应激的影响；在这项研究中，我们旨在评估早期或晚期脐带夹闭对足月新生儿氧化应激的影响，并评估氧化应激与脐血脂质的关系。
方法
本研究纳入了 100 名母亲及其足月新生儿。分娩后立即从脐静脉和脐动脉采集脐带血样本。
结果
ECC 组总胆固醇、总甘油三酯和磷脂水平明显高于 DCC 组（均<0.001）。DCC 组血浆总抗氧化状态高于 ECC 组（<0.001）。而 DCC 组血浆羟自由基水平低于 ECC 组（<0.001）。DCC 组红细胞胞浆过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶水平明显高于 ECC 组（均<0.001）。
结论
DCC 与脐带血脂质降低和抗氧化活性增强有关。这表明 DCC 对足月新生儿未来健康具有保护作用，并支持在足月新生儿第三产程中积极应用 DCC。
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