Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
Transbound Emerg Dis. 2018 May;65 Suppl 1:186-198. doi: 10.1111/tbed.12729. Epub 2017 Nov 10.
Since the first report of bovine digital dermatitis (DD) in 1974, there is a large body of the literature published; however, effective prevention and control of the disease remain elusive. Although many aspects of the pathogenesis of DD have been investigated, even some of the most basic questions such as the aetiology of this disease remain under debate. Treponema spp. have been strongly associated with DD lesions and occur in abundance in advanced lesions; however, efforts to induce disease with pure cultures of these organisms have been largely underwhelming and inconsistent. Furthermore, although the disease has been presented for several decades, there is limited scientific evidence regarding effective treatment of DD. Apparent discrepancies between effectiveness in vitro and in vivo have challenged the scientific community to identify new potential treatment options. With no treatment resulting in a 100% cure rate, the current expectation is manageable control, but prospects for the eradication of the disease are unlikely using current approaches. In order to develop more effective approaches to control DD on-farm, there is a critical need for a deeper understanding regarding the causation, ecology, transmission and treatment of this disease. In this article, we attempt to provide insights into specific research needs related to DD in order to assist the industry, researchers, pharmaceutical companies and research sponsors with decision-making and identified research gaps.
自 1974 年首次报道牛传染性皮肤病（DD）以来，已有大量文献发表；然而，该病的有效预防和控制仍难以实现。尽管已经对 DD 的发病机制进行了多方面的研究，甚至一些最基本的问题，如这种疾病的病因，仍存在争议。密螺旋体属与 DD 病变密切相关，在晚期病变中大量存在；然而，用这些纯培养物诱导疾病的努力在很大程度上令人失望且不一致。此外，尽管这种疾病已经存在了几十年，但关于 DD 的有效治疗方法的科学证据有限。体外和体内效果之间的明显差异，促使科学界寻找新的潜在治疗选择。由于没有一种治疗方法能达到 100%的治愈率，目前的期望是进行可控的治疗，但使用当前方法不太可能根除这种疾病。为了在农场层面制定更有效的 DD 控制方法，我们迫切需要深入了解该病的病因、生态学、传播和治疗。在本文中，我们试图提供与 DD 相关的特定研究需求的见解，以帮助行业、研究人员、制药公司和研究赞助商做出决策，并确定研究差距。
