术前正电子发射断层扫描/计算机断层扫描在磨玻璃密度成分小于30毫米的肺腺癌中的最大标准化摄取值

The maximum standardized uptake value of preoperative positron emission tomography/computed tomography in lung adenocarcinoma with a ground-glass opacity component of less than 30 mm.

作者信息

Son Bong Y, Cho Sukki, Yum Sung W, Kim Kwhanmien, Jheon Sanghoon

机构信息

Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Republic of Korea.

Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Republic of Korea.

出版信息

J Surg Oncol. 2018 Mar;117(3):451-456. doi: 10.1002/jso.24857. Epub 2017 Nov 11.

DOI:10.1002/jso.24857

PMID:29127699

Abstract

BACKGROUND AND OBJECTIVES

This study evaluated the relationship between the maximum standardized uptake value (SUVmax) of preoperative positron emission tomography/computed tomography (PET/CT) and the characteristics of lung adenocarcinoma featuring ground-glass opacity nodules (GGN).

METHODS

The association of the SUVmax of preoperative PET/CT with ground-glass opacity (GGO) proportion on CT, subtypes of adenocarcinoma (minimally invasive adenocarcinoma, invasive adenocarcinoma), predominant types of invasive adenocarcinoma, and size of the total and invasive components of pathology were evaluated in 190 patients who underwent resection for lung adenocarcinoma featuring GGN.

RESULTS

The mean SUVmax of non-solid GGN and partly solid GGN were 0.53 and 1.32, respectively (P = 0.029). The mean SUVmax of the main masses in 38 patients with MIA and 152 with invasive adenocarcinoma were 0.86 and 1.36, respectively (P = 0.029). The mean SUVmax of acinar, lepidic, papillary, and solid tumors were 1.61, 0.87, 0.98, and 1.60, respectively. The mean SUVmax of invasive components measuring ≤10 mm, 11-20 mm, and >20 mm were 0.84, 1.66, and 2.09, respectively (P < 0.001).

CONCLUSIONS

The SUVmax of lung adenocarcinoma featuring GGN can vary depending on the GGO proportion. A higher SUVmax can be expected in invasive adenocarcinoma than in MIA, and solid and acinar-predominant invasive adenocarcinoma showed a higher SUVmax.

摘要

背景与目的

本研究评估了术前正电子发射断层扫描/计算机断层扫描（PET/CT）的最大标准化摄取值（SUVmax）与以磨玻璃影结节（GGN）为特征的肺腺癌特征之间的关系。

方法

对190例接受手术切除的以GGN为特征的肺腺癌患者，评估术前PET/CT的SUVmax与CT上磨玻璃影（GGO）比例、腺癌亚型（微浸润腺癌、浸润性腺癌）、浸润性腺癌的主要类型以及病理上总成分和浸润成分大小之间的关联。

结果

非实性GGN和部分实性GGN的平均SUVmax分别为0.53和1.32（P = 0.029）。38例微浸润腺癌和152例浸润性腺癌患者主要肿块的平均SUVmax分别为0.86和1.36（P = 0.029）。腺泡状、鳞屑状、乳头状和实性肿瘤的平均SUVmax分别为1.61、0.87、0.98和1.60。浸润成分测量值≤10 mm、11 - 20 mm和>20 mm的平均SUVmax分别为0.84、1.66和2.09（P < 0.001）。