肥胖儿童循环氧化低密度脂蛋白与代谢综合征的关系：高甘油三酯腰围表型的作用。

Relation between circulating oxidized-LDL and metabolic syndrome in children with obesity: the role of hypertriglyceridemic waist phenotype.

作者信息

Calcaterra Valeria, De Giuseppe Rachele, Biino Ginevra, Mantelli Melissa, Marchini Sonia, Bendotti Giulia, Madè Alexandra, Avanzini Maria Antonietta, Montalbano Chiara, Cossellu Gianguido, Larizza Daniela, Cena Hellas

机构信息

出版信息

J Pediatr Endocrinol Metab. 2017 Nov 27;30(12):1257-1263. doi: 10.1515/jpem-2017-0239.

DOI:10.1515/jpem-2017-0239

PMID:29127769

Abstract

BACKGROUND

The association between oxidative stress (OS) and metabolic syndrome (MetS) has been reported in adults. We analyzed the relation between circulating oxidized low-density lipoproteins (Ox-LDL) and MetS in pediatric ages in order to define whether plasma Ox-LDL levels are correlated to obesity and whether oxidative damage, using serum Ox-LDL levels as a proxy, are associated with MetS.

METHODS

We enrolled 178 children (11.8±2.6 years). On the basis of a body mass index (BMI) threshold, the subjects were classified as: normal weight BMI <75th percentile; overweight BMI 75-97th percentile; obese BMI >97th percentile. Patients were classified as having MetS if they met three or more of the following criteria for age and sex: BMI >97th percentile, triglyceride levels >95th percentile, high-density lipoprotein (HDL) cholesterol level <5th percentile, systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) >95th percentile and impaired glucose tolerance.

RESULTS

Obese children showed increased MetS prevalence (p=0.001) and higher Ox-LDL levels compared to normal- and overweight subjects (p<0.05), with a limited relation between Ox-LDL and MetS (p=0.06). Waist-to-height ratio (W/HtR) (p=0.02), triglycerides (TG) (p=0.001) and LDL-cholesterol (p<0.001) resulted independent predictors of increased plasma Ox-LDL levels.

CONCLUSIONS

Oxidative damage was correlated with a hypertriglyceridemic waist phenotype and can be a precocious marker of MetS and cardiometabolic risk in obese children.

摘要

背景

氧化应激（OS）与成人代谢综合征（MetS）之间的关联已有报道。我们分析了儿童期循环氧化型低密度脂蛋白（Ox-LDL）与MetS之间的关系，以确定血浆Ox-LDL水平是否与肥胖相关，以及以血清Ox-LDL水平为代表的氧化损伤是否与MetS相关。

方法

我们纳入了178名儿童（11.8±2.6岁）。根据体重指数（BMI）阈值，将受试者分为：正常体重BMI<第75百分位数；超重BMI第75-97百分位数；肥胖BMI>第97百分位数。如果患者符合以下针对年龄和性别的三项或更多标准，则被分类为患有MetS：BMI>第97百分位数、甘油三酯水平>第95百分位数、高密度脂蛋白（HDL）胆固醇水平<第5百分位数、收缩压（SBP）和/或舒张压（DBP）>第95百分位数以及糖耐量受损。

结果

与正常体重和超重受试者相比，肥胖儿童的MetS患病率增加（p=0.001）且Ox-LDL水平更高（p<0.05），Ox-LDL与MetS之间的关系有限（p=0.06）。腰高比（W/HtR）（p=0.02）、甘油三酯（TG）（p=0.001）和低密度脂蛋白胆固醇（p<0.001）是血浆Ox-LDL水平升高的独立预测因素。