Shen Yong, Li Rena
Neurodegenerative Disorder Research Center (NDRC), School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA.
J Sport Health Sci. 2016 Dec;5(4):397-399. doi: 10.1016/j.jshs.2016.10.002. Epub 2016 Oct 21.
Alzheimer's disease (AD) is the most common form of dementia in elderly with major symptoms of a general term for memory loss and other intellectual abilities impairment which are serious enough to interfere with daily life. While there is no treatment can prevent and revise the cognitive function impairment in AD, physical activity becomes a potential beneficial intervention for AD. Multiple evidences suggested that exercise in general plays beneficial roles in improving brain function. Most common mechanisms of exercise-induced enhancement of brain function are including alteration of neurogenesis, neuron plasticity, neuronal signaling and receptors, as well as neuronal networks. This mini review includes most recent clinical studies and focuses on the effects of physical exercise, cognitive stimulation, and combination of both physical and cognitive training on protection and rescue cognitive decline in people with AD.
阿尔茨海默病（AD）是老年人中最常见的痴呆形式，主要症状是记忆力丧失和其他智力能力受损的统称，严重到足以干扰日常生活。虽然目前尚无治疗方法能够预防和逆转AD患者的认知功能损害，但体育活动成为AD潜在的有益干预措施。多项证据表明，一般来说运动对改善脑功能具有有益作用。运动诱导脑功能增强的最常见机制包括神经发生、神经元可塑性、神经元信号传导和受体以及神经网络的改变。本综述纳入了最新的临床研究，并重点关注体育锻炼、认知刺激以及体育与认知训练相结合对AD患者保护和挽救认知衰退的影响。
