Tong Zhichao, Liu Yang, Chen Bo, Yan Liang, Hao Dingjun
Department of Bone Diesase and Bone Tumor, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Shaanxi 710054, China.
Department of Orthopaedics, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Shaanxi 710054, China.
Oncotarget. 2017 Jun 27;8(48):83563-83569. doi: 10.18632/oncotarget.18745. eCollection 2017 Oct 13.
Osteoarthritis (OA) is the most commonly occurring degenerative joint disease worldwide, and its incidence has increased in recent years. We evaluated whether there is the association between and variants and susceptibility to OA in a Chinese population. Venous blood samples were collected from 431 female participants (200 cases and 231 controls) at Hong Hui Hospital, Xi'an Jiaotong University College of Medicine between 2015 and 2016. After genotyping the samples using standard protocols, the association between and single nucleotide polymorphisms and risk of OA was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditional logistic regression analysis. The minor G allele of rs650108 was associated with OA risk in a recessive model ( = 0.034, OR = 1.82, 95%CI = 1.04-3.18), while the minor A allele of rs715572 was associated with OA risk in a recessive model ( 0.030, OR = 1.88, 95%CI = 1.05-3.34). Thus a suggestive association was observed in a discovery case-control study between OA and two common SNPs, rs650108 in and rs715572 in .
骨关节炎（OA）是全球最常见的退行性关节疾病，近年来其发病率有所上升。我们评估了在中国人群中，[具体基因名称1]和[具体基因名称2]的变异与OA易感性之间是否存在关联。2015年至2016年期间，在西安交通大学医学院附属红会医院采集了431名女性参与者（200例病例和231名对照）的静脉血样本。使用标准方案对样本进行基因分型后，通过无条件逻辑回归分析计算比值比（OR）和95%置信区间（95%CI），评估[具体基因名称1]和[具体基因名称2]的单核苷酸多态性与OA风险之间的关联。rs650108的次要G等位基因在隐性模型中与OA风险相关（P = 0.034，OR = 1.82，95%CI = 1.04 - 3.18），而rs715572的次要A等位基因在隐性模型中与OA风险相关（P = 0.030，OR = 1.88，95%CI = 1.05 - 3.34）。因此，在一项发现性病例对照研究中，观察到OA与两个常见单核苷酸多态性（[具体基因名称1]中的rs650108和[具体基因名称2]中的rs715572）之间存在提示性关联。
