心血管疾病中免疫系统的自主调节
Autonomic regulation of the immune system in cardiovascular diseases.
作者信息
Abboud François M, Singh Madhu V
机构信息
Departments of Internal Medicine and Molecular Physiology and Biophysics, Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa
Departments of Internal Medicine and Molecular Physiology and Biophysics, Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
出版信息
Adv Physiol Educ. 2017 Dec 1;41(4):578-593. doi: 10.1152/advan.00061.2017.
The autonomic nervous system is a powerful regulator of circulatory adjustments to acute hemodynamic stresses. Here we focus on new concepts that emphasize the chronic influence of the sympathetic and parasympathetic systems on cardiovascular pathology. The autonomic neurohumoral system can dramatically influence morbidity and mortality from cardiovascular disease through newly discovered influences on the innate and adaptive immune systems. Specifically, the end-organ damage in heart failure or hypertension may be worsened or alleviated by pro- or anti-inflammatory pathways of the immune system, respectively, that are activated through neurohumoral transmitters. These concepts provide a major new perspective on potentially life-saving therapeutic interventions in the deadliest of diseases.
自主神经系统是对急性血流动力学应激进行循环调节的强大调节器。在此，我们关注一些新概念，这些概念强调交感和副交感神经系统对心血管病理的慢性影响。自主神经体液系统可通过对先天和适应性免疫系统的新发现影响，显著影响心血管疾病的发病率和死亡率。具体而言，心力衰竭或高血压中的终末器官损伤可能分别通过免疫系统的促炎或抗炎途径而加重或减轻，这些途径是由神经体液递质激活的。这些概念为最致命疾病中潜在的救命治疗干预提供了一个重要的新视角。
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