高剂量鞘内注射甲氨蝶呤治疗肺腺癌继发癌性脑膜炎的临床改善及生存期延长
Clinical Improvement and Prolonged Survival With High Dose Intrathecal Methotrexate for Carcinomatous Meningitis Secondary to a Lung Adenocarcinoma.
作者信息
Clatot Florian, David Philippe, Laberge-Le-Couteulx Sophie, Blot Emmanuel
机构信息
Department of Medical Oncology, Centre Henri Becquerel, Rouen, France.
Department of Pneumology, CHI Les Feugrais, Elbeuf, France.
出版信息
World J Oncol. 2011 Oct;2(5):262-264. doi: 10.4021/wjon358w. Epub 2011 Oct 28.
Abstract
Carcinomatous meningitis (CM) is a devastating complication of advanced cancers. No standard treatment is available for CM secondary to solid tumors. In particular, very few data have been published for CM related to lung adenocarcinoma. Herein we report the case of a 39-year old woman treated for a metastatic lung adenocarcinoma, without EGFR mutation, complicated by a CM. Intrathecal administrations of high dose methotrexate produced both a clinical improvement of symptoms related to CM and an unusually delayed survival.
摘要
癌性脑膜炎（CM）是晚期癌症的一种毁灭性并发症。对于实体瘤继发的CM，尚无标准治疗方法。特别是，与肺腺癌相关的CM的 published数据非常少。在此，我们报告一例39岁女性，患有转移性肺腺癌且无EGFR突变，并发CM，接受了高剂量甲氨蝶呤鞘内注射治疗，症状得到临床改善，生存期也出现异常延长。 （注：原文中“published”疑似拼写错误，可能应为“published”，这里按修正后翻译）
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