Yu Zhou, Pang Yifan, Wang Linda, Ezekwudo Daniel E, Ogunleye Foluso, Gaikazian Susanna S, Micale Mark, Huang James, Blenc Ann Marie, Jaiyesimi Ishmael
Department of Hematology and Oncology, William Beaumont Hospital, Royal Oak, MI, USA.
Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
Case Rep Hematol. 2017;2017:7292148. doi: 10.1155/2017/7292148. Epub 2017 Sep 24.
We report a case of a small-cell variant of anaplastic large-cell lymphoma, with an unusual clinical presentation mimicking sepsis and a fulminant clinic course, in a 48-year-old Caucasian female. In this report, we discuss the diagnostic challenge, histopathologic features, and unique cytogenetic features of this case, in order to raise awareness of this rare presentation and emphasize the importance of meticulous peripheral smear examination and early bone marrow evaluation.
我们报告了一例间变性大细胞淋巴瘤的小细胞变异型病例,患者为一名48岁的白种女性,临床表现异常,类似败血症,临床病程凶险。在本报告中,我们讨论了该病例的诊断挑战、组织病理学特征和独特的细胞遗传学特征,以提高对这种罕见表现的认识,并强调仔细进行外周血涂片检查和早期骨髓评估的重要性。