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一名HIV-1感染患者由消化链球菌引起的化脓性脑脓肿

Pyogenic Brain Abscess Caused by Peptostreptococcus in a Patient with HIV-1 Infection.

作者信息

Gonzales Zamora Jose Armando, Espinoza Luis Alberto

机构信息

Division of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.

Gilead Sciences, Miami, FL 33136, USA.

出版信息

Diseases. 2017 Nov 17;5(4):26. doi: 10.3390/diseases5040026.

Abstract

In the setting of HIV, cerebral lesions are usually secondary to lymphoma and opportunistic infections; however, in patients with CD4 counts above 200 cells/uL, other pathologies such as pyogenic brain abscess could gain importance. The microbiology of pyogenic brain abscess has and as the leading etiologic pathogens in immunocompetent individuals. is also recognized as a common cause of brain abscess in this patient population. In HIV-infected individuals, there have been sporadic reports of infections but none of brain abscess. We describe the case of a 43-years-old HIV-infected patient with a CD4 count of 350 cells/uL that developed a brain abscess presumably from hematogenous spread of an odontogenic source. Treatment with stereotactic needle aspiration in two opportunities and four weeks of intravenous antibiotics led to a complete resolution of this infection. This case highlights the importance of a multidisciplinary approach for an effective treatment of pyogenic brain abscess in HIV-1 patients.

摘要

在艾滋病病毒感染的情况下,脑部病变通常继发于淋巴瘤和机会性感染;然而,对于CD4细胞计数高于200个/微升的患者,其他病理情况如化脓性脑脓肿可能变得重要。在免疫功能正常的个体中,化脓性脑脓肿的微生物学特征是以[未提及的两种病原体]作为主要病因病原体。[未提及的一种病原体]在该患者群体中也被认为是脑脓肿的常见病因。在感染艾滋病病毒的个体中,有关于[未提及的病原体]感染的零星报道,但没有脑脓肿的报道。我们描述了一例43岁的艾滋病病毒感染患者,其CD4细胞计数为350个/微升,发生了[未提及的脑脓肿情况],推测是由牙源性来源的血行播散引起的。两次立体定向针吸治疗以及四周的静脉抗生素治疗使该感染完全消退。该病例强调了多学科方法对有效治疗HIV-1患者化脓性脑脓肿的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2235/5750537/5995fc7203d8/diseases-05-00026-g001.jpg

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