Kurtulus F O, Salman M Y, Fazlioglu A, Fazlioglu B
Kolan International Hospital, Urology, Istanbul, Turkey.
Tirebolu State Hospital, Urology, Giresun, Turkey.
Transplant Proc. 2017 Nov;49(9):2099-2104. doi: 10.1016/j.transproceed.2017.07.014.
Sexual dysfunction occurs commonly in individuals with end-stage renal disease. Chronic renal failure as well as the treatments used for it generally has a negative impact on sexual function with a subsequent increase in the risk of depression. There is scarcity of published data on female sexual dysfunction and the degree of improvement in patients on hemodialysis (HD) and transplant (Tx) recipients. The aim of this study was to compare the sexual function and degree of depression in HD and Tx patients with control group. For this purpose, we used the validated Female Sexual Function Index (FSFI) and Beck Depression Inventory (BDI).
A total of 23 renal Tx, 29 HD, and 30 control patients were enrolled in the study. HD patients were required to be undergoing HD for ≥6 months, and for renal Tx recipients, the Tx had to be performed ≥6 months before study entry. All women underwent a general and urogynecologic examination. Demographic and clinical variables were documented. FSFI and BDI scale scores were compared among groups.
The rates of female sexual dysfunction were 56.7%, 89.7%, and 73.9% in the control, HD, and Tx, patients respectively. Total FSFI scores in HD group were significantly lower than those in Tx and control patients (P < .05). FSFI scores improved significantly in the Tx group. BDI scores in HD and control subjects were 23.24 and 14.17, respectively, with a significant difference between the 2 groups (P < .005). BDI score in the Tx group was 16.65 and the difference was statistically insignificant.
This preliminary study documented that successful Tx may positively affect sexual life in women with chronic renal failure. A diagnosis of female sexual dysfunction should be made routinely in patients with chronic renal failure.
性功能障碍在终末期肾病患者中很常见。慢性肾衰竭及其治疗方法通常会对性功能产生负面影响，进而增加抑郁风险。关于女性性功能障碍以及血液透析（HD）患者和肾移植（Tx）受者病情改善程度的已发表数据较少。本研究的目的是比较HD患者和Tx患者与对照组的性功能及抑郁程度。为此，我们使用了经过验证的女性性功能指数（FSFI）和贝克抑郁量表（BDI）。
本研究共纳入23例肾移植患者、29例HD患者和30例对照患者。HD患者需已接受HD治疗≥6个月，肾移植受者则需在研究入组前≥6个月接受移植手术。所有女性均接受了全面的泌尿妇科检查。记录了人口统计学和临床变量。比较了各组的FSFI和BDI量表评分。
对照组、HD组和Tx组患者的女性性功能障碍发生率分别为56.7%、89.7%和73.9%。HD组的FSFI总分显著低于Tx组和对照组患者（P <.05）。Tx组的FSFI评分显著改善。HD组和对照组的BDI评分分别为23.24和14.17，两组间差异有统计学意义（P <.005）。Tx组的BDI评分为16.65，差异无统计学意义。
这项初步研究表明，成功的肾移植可能对慢性肾衰竭女性的性生活产生积极影响。慢性肾衰竭患者应常规进行女性性功能障碍的诊断。
