来自突尼斯生长的克里特蓍草的新型细胞毒性倍半萜内酯。
New cytotoxic sesquiterpene lactones from Achillea cretica L. growing in Tunisia.
作者信息
Hichri Fayçal, Znati Mansour, Bouajila Jalloul, Ben Jannet Hichem
机构信息
a Department of Chemistry, College of Science for Girls in Abha , King Khalid University , Abha , Saudi Arabia.
b Laboratoire de Chimie hétérocyclique, Produits Naturels et Réactivité, Equipe: Chimie Médicinale et Produits Naturels, Faculté des Sciences de Monastir , Université de Monastir , Monastir 5019 , Tunisia.
出版信息
J Asian Nat Prod Res. 2018 Apr;20(4):344-351. doi: 10.1080/10286020.2017.1355362. Epub 2017 Nov 21.
The phytochemical study of Achillea cretica growing in Tunisia led to the isolation of two novel sesquiterpene lactones, which have been designated achicretin 1 and achicretin 2. Their chemical structures were further confirmed by mass spectroscopy (ESI-MS) and by extensive application of one- and two-dimensional NMR spectroscopy. The isolated compounds were tested for their cytotoxic activity against four human cancer cell lines, IGROV-1, OVCAR-3, MCF-7, and HCT-116 using the MTT assay. It has been found that achicretin 2 exhibited more potent inhibitory activity with IC = values of 14.0 ± 1.0 and 16.0 ± 2.0 μM against OVCAR-3 and HCT-116 cells, respectively.
对生长在突尼斯的克里特蓍草进行的植物化学研究，导致分离出两种新型倍半萜内酯，分别命名为蓍草素1和蓍草素2。通过质谱（ESI-MS）以及广泛应用一维和二维核磁共振光谱进一步证实了它们的化学结构。使用MTT法对分离出的化合物针对四种人类癌细胞系IGROV-1、OVCAR-3、MCF-7和HCT-116进行细胞毒性活性测试。已发现蓍草素2表现出更强的抑制活性，对OVCAR-3和HCT-116细胞的IC₅₀值分别为14.0±1.0和16.0±2.0μM。
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