Park Jong Seol, Park Ji Eun, Oh Byoung Soo, Yoon Byung Wook, Kim Hyun Ki, Lee Jae Won, Kim Nam Ho, Cho Won Seok, Woo Young Sik, Jahng Jaehoon, Kim Yong Sung
Department of Internal Medicine and Wonkwang Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, Gunpo, Korea.
Graduate School of Public Health, Seoul National University, Seoul, Korea.
Korean J Gastroenterol. 2017 Nov 25;70(5):232-238. doi: 10.4166/kjg.2017.70.5.232.
BACKGROUND/AIMS: The eradication rate of () has been decreasing recently in Korea due to antibiotics resistance. The aim of this study was to investigate the trend of eradication rate and clinical factors affecting the eradication rate of in the last 10 years in west Gyeonggi-do, Korea.
The trends of eradication rate of , gender, age, concomitant mediations, and clinical factors were retrospectively evaluated in patients with infection between 2006 and 2015 (n=2,485).
The overall eradication rate for the standard triple therapy was 82.5%. The annual eradication rates from 2006 to 2015 were 90%, 77.9%, 75.8%, 83.2%, 85.6%, 90.1%, 81.3%, 81.1%, 78.7%, and 78.8%, respectively, showing a significant decrement during the last five years (p<0.001). Higher eradication rate was observed in males than in females (p<0.001). Esomeprazole showed a higher eradication rate compared with pantoprazole between 2006 and 2010 (p<0.022). Age and the use of probiotics and mucosal protective agents played no significant role in the eradication rate. The overall eradication rate for bismuth-based quadruple therapy was 94.4%.
The eradication rate of over the last 10 years for first-line therapy ranged from 75.8 to 90.1%; the eradication rate for triple therapy has declined. However, the eradication rate for quadruple therapy has remained unchanged over the last 10 years.
背景/目的：由于抗生素耐药性，韩国幽门螺杆菌（Hp）根除率最近一直在下降。本研究旨在调查韩国京畿道西部过去10年中幽门螺杆菌根除率的趋势以及影响根除率的临床因素。
对2006年至2015年间2485例幽门螺杆菌感染患者的根除率趋势、性别、年龄、伴随用药及临床因素进行回顾性评估。
标准三联疗法的总体幽门螺杆菌根除率为82.5%。2006年至2015年的年根除率分别为90%、77.9%、75.8%、83.2%、85.6%、90.1%、81.3%、81.1%、78.7%和78.8%，在过去五年中显著下降（p<0.001）。男性的根除率高于女性（p<0.001）。2006年至2010年间，埃索美拉唑的根除率高于泮托拉唑（p<0.022）。年龄以及益生菌和黏膜保护剂的使用对幽门螺杆菌根除率无显著影响。铋剂四联疗法的总体根除率为94.4%。
过去10年一线治疗幽门螺杆菌的根除率为75.8%至90.1%；三联疗法的根除率有所下降。然而，四联疗法的根除率在过去10年中保持不变。
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