单次给予百草枯后大鼠肺中金属硫蛋白-I的蓄积

Metallothionein-I accumulation in the rat lung following a single paraquat administration.

作者信息

Sato M, Ohtake A, Takeda K, Mizunuma H, Nagai Y

机构信息

Division of Environmental Pollution Research, Fukushima Medical College, Japan.

出版信息

Toxicol Lett. 1989 Jan;45(1):41-7. doi: 10.1016/0378-4274(89)90157-4.

DOI:10.1016/0378-4274(89)90157-4

PMID:2916248

Abstract

The ability of paraquat (PQ), a free radical inducible chemical, to increase metallothionein-I (MT-I) content in the tissues was determined using radioimmunoassay. A single dose of PQ into the rat caused a sevenfold increase in pulmonary MT-I concentration on day 1 and its concentration returned to the control level by day 5. Paraquat-induced increase in MT-I was not observed in the kidney, but was seen in the liver. The data show the difference in accumulation of MT-I in liver, kidney and lung after intraperitoneal injection of a high dose of PQ.

摘要

利用放射免疫分析法测定了百草枯（PQ，一种可诱导自由基的化学物质）增加组织中金属硫蛋白-I（MT-I）含量的能力。给大鼠单次注射PQ后，第1天肺组织中MT-I浓度增加了7倍，到第5天时其浓度恢复到对照水平。在肾脏中未观察到百草枯诱导的MT-I增加，但在肝脏中观察到了。数据显示，腹腔注射高剂量PQ后，肝脏、肾脏和肺中MT-I的蓄积存在差异。