触珠蛋白和转铁蛋白的基因变异与肾细胞癌的DNA含量及分期的关系

Genetic variation of haptoglobin and transferrin in relation to DNA content and stage in renal cell carcinoma.

作者信息

Fröhlander N, Ljungberg B, Roos G

机构信息

Department of Medical Genetics, University of Umeå, Sweden.

出版信息

Cancer. 1989 Mar 15;63(6):1138-42. doi: 10.1002/1097-0142(19890315)63:6<1138::aid-cncr2820630616>3.0.co;2-p.

DOI:10.1002/1097-0142(19890315)63:6<1138::aid-cncr2820630616>3.0.co;2-p

PMID:2917316

Abstract

Four genetic marker systems were investigated in 102 patients with renal cell carcinoma. The previously observed excess of the transferrin (TF) variant C3 among male patients was confirmed. Interestingly, an excess of TFC3 and a deficit of the haptoglobin heterozygote, HP2-1, were associated with diploid tumor DNA content and Stage I, particularly in male patients. The results are discussed in terms of a possible genetic influence on tumor progression.

摘要

对102例肾细胞癌患者的四个遗传标记系统进行了研究。此前观察到的男性患者中转铁蛋白（TF）变体C3过多的现象得到了证实。有趣的是，TFC3过多和触珠蛋白杂合子HP2-1缺乏与二倍体肿瘤DNA含量和I期相关，特别是在男性患者中。从对肿瘤进展可能的遗传影响方面对结果进行了讨论。