用于治疗儿童葡萄球菌感染的新型抗菌药物
New Antimicrobial Agents for the Treatment of Staphylococcal Infections in Children.
作者信息
Sharma Roopali, Francois Densley, Hammerschlag Margaret R
机构信息
Department of Pharmacy Practice, Touro College of Pharmacy, 230 West 125th Street, New York, NY 10027, USA; Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
Department of Pharmacy, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA; Department of Pediatrics, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
出版信息
Pediatr Clin North Am. 2017 Dec;64(6):1369-1387. doi: 10.1016/j.pcl.2017.08.005.
Several new antimicrobial agents-daptomycin, ceftaroline, telavancin, dalbavancin, and-tedizolid have been approved for the treatment of staphylococcal infections, including methicillin-resistant Staphylococcus aureus (MRSA), in adults. Ceftaroline and daptomycin have been approved by the US Food and Drug Administration for use in children. Ceftaroline, a beta-lactam antibiotic with activity against MRSA, has been approved for treatment of community-acquired bacterial pneumonia and complicated skin and skin structure infections. Daptomycin has been approved for treatment of complicated skin and skin structure infections. In this article, we review the pharmacokinetics and pharmacodynamics of these antibiotics and available data on use in children.
几种新型抗菌药物——达托霉素、头孢洛林、替加环素、达巴万星和特地唑胺已被批准用于治疗成人葡萄球菌感染，包括耐甲氧西林金黄色葡萄球菌（MRSA）感染。头孢洛林和达托霉素已获美国食品药品监督管理局批准用于儿童。头孢洛林是一种对MRSA有活性的β-内酰胺类抗生素，已被批准用于治疗社区获得性细菌性肺炎以及复杂性皮肤和皮肤结构感染。达托霉素已被批准用于治疗复杂性皮肤和皮肤结构感染。在本文中，我们综述了这些抗生素的药代动力学和药效学以及儿童用药的现有数据。
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