线粒体 DNA 在能量代谢中的作用。

Roles of Mitochondrial DNA in Energy Metabolism.

机构信息

Zhongshan Hospital Institute of Fudan University, Shanghai Medical School, Shanghai, China.

Department of Pathology, University of Otago, Wellington, New Zealand.

出版信息

Adv Exp Med Biol. 2017;1038:71-83. doi: 10.1007/978-981-10-6674-0_6.

DOI:10.1007/978-981-10-6674-0_6

PMID:29178070

Abstract

Mitochondria are independent double-membrane organelles responsible for energy production, specifically by completing oxidative phosphorylation. Mitochondria are essential to regulate energy metabolism, signaling pathways, and cell death. Mitochondrial DNA (mtDNA) can be altered by metabolic disorders, oxidative stress, or inflammation in the progression and development of various diseases. In this chapter, we overview the role of mtDNA in energy metabolism and the diseases that are associated with mtDNA abnormality, with a special focus on the major factors which regulate the mechanism of mtDNA in metabolism.

摘要

线粒体是独立的双层膜细胞器，负责能量产生，特别是通过完成氧化磷酸化。线粒体对于调节能量代谢、信号通路和细胞死亡至关重要。线粒体 DNA（mtDNA）可以在各种疾病的发生和发展中通过代谢紊乱、氧化应激或炎症而改变。在本章中，我们概述了 mtDNA 在能量代谢中的作用以及与 mtDNA 异常相关的疾病，并特别关注调节 mtDNA 代谢机制的主要因素。