薯蓣皂苷元-2-氨基-2-脱氧-β-D-吡喃半乳糖苷：合成、衍生物及抗菌活性
Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity.
作者信息
Myszka Henryk, Sokołowska Patrycja, Cieślińska Agnieszka, Nowacki Andrzej, Jaśkiewicz Maciej, Kamysz Wojciech, Liberek Beata
机构信息
Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Faculty of Pharmacy, Medical University of Gdańsk, Hallera 107, 80-416 Gdańsk, Poland.
出版信息
Beilstein J Org Chem. 2017 Nov 1;13:2310-2315. doi: 10.3762/bjoc.13.227. eCollection 2017.
The synthesis of diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside is presented for the first time. This synthetic saponin was transformed into its hydrochloride as well as -acyl, 2-ureido, -alkyl, and ,-dialkyl derivatives. Antifungal and antibacterial studies show that some of the obtained compounds are active against Gram-positive bacteria and type fungi.
首次报道了薯蓣皂苷元2-氨基-2-脱氧-β-D-吡喃半乳糖苷的合成。这种合成皂苷被转化为其盐酸盐以及酰基、2-脲基、烷基和二烷基衍生物。抗真菌和抗菌研究表明，所得到的一些化合物对革兰氏阳性菌和某些类型的真菌具有活性。
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