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儿童股骨骨折外固定与弹性髓内钉治疗的荟萃分析。

A meta-analysis of external fixation and flexible intramedullary nails for femoral fractures in children.

作者信息

Zhang Y-T, Jin D, Niu J, Li Z-J, Fu S, Zou Z-L

出版信息

Acta Orthop Belg. 2016 Dec;82(4):673-680.

Abstract

BACKGROUND

The purpose of this meta-analysis was to compare the outcomes of external fixation and flexible intramedullary nails for femoral fractures in children between 5 and 15 years of age based on the current evidence.

MATERIALS AND METHODS

We searched relevent studies in the following database: Cochrane library, PubMed and EMABASE up to May 2014. All randomized controlled trials, Clinical controlled trials and retrospective controlled studies comparing external fixation and flexible intramedullary nails in femoral fractures of children were included. Data was extracted independently for meta-analysis.

RESULTS

Seven trials altogether involving 338 cases of femoral fractures of children treated by external fixation (128 cases) and flexible intramedullary nails (210 cases) were included in the meta-analysis. Results showed that flexible intramedullary nails was superior to external fixation in less time to union , lower postoperative infection rate and refracture rate . It may not increase delayed union, Limb-length discrepancy , pain and bursitis . Both fixations obtained a similar patient satisfaction.

CONCLUSION

Flexible intramedullary nail had greater advantages for the treatment of femoral fractures in children aged 5-15 years, compared to external fixation based on current meta-analysis. This conclusion will ultimately require rigorous and adequately powered randomized controlled trials to be proved.

摘要

背景

本荟萃分析的目的是基于现有证据,比较5至15岁儿童股骨骨折采用外固定和弹性髓内钉治疗的效果。

材料与方法

我们检索了截至2014年5月的以下数据库中的相关研究:Cochrane图书馆、PubMed和EMABASE。纳入所有比较儿童股骨骨折外固定和弹性髓内钉治疗的随机对照试验、临床对照试验和回顾性对照研究。独立提取数据进行荟萃分析。

结果

荟萃分析共纳入7项试验,涉及338例接受外固定(128例)和弹性髓内钉治疗(210例)的儿童股骨骨折病例。结果显示,弹性髓内钉在骨折愈合时间更短、术后感染率和再骨折率更低方面优于外固定。它可能不会增加延迟愈合、肢体长度差异、疼痛和滑囊炎。两种固定方式的患者满意度相似。

结论

基于目前的荟萃分析,与外固定相比,弹性髓内钉在治疗5至15岁儿童股骨骨折方面具有更大优势。这一结论最终需要严格且有足够效力的随机对照试验来证实。

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