TPL2 激酶的作用及其对炎症的调控。
TPL2 kinase action and control of inflammation.
机构信息
Genentech Research, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Genentech Research, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
出版信息
Pharmacol Res. 2018 Mar;129:188-193. doi: 10.1016/j.phrs.2017.11.031. Epub 2017 Nov 26.
Tumor progression locus 2 (TPL2, also known as COT or MAP3K8) is a mitogen-activated protein kinase kinase (MAP3K) activated downstream of TNFαR, IL1R, TLR, CD40, IL17R, and some GPCRs. TPL2 regulates the MEK1/2 and ERK1/2 pathways to regulate a cascade of inflammatory responses. In parallel to this, TPL2 also activates p38α and p38δ to drive the production of various inflammatory mediators in neutrophils. We discuss the implications of this finding in the context of various inflammatory diseases.
肿瘤进展基因座 2（TPL2，也称为 COT 或 MAP3K8）是一种丝裂原活化蛋白激酶激酶（MAP3K），可被 TNFαR、IL1R、TLR、CD40、IL17R 和一些 GPCR 下游激活。TPL2 调节 MEK1/2 和 ERK1/2 途径，以调节一连串的炎症反应。与此平行的是，TPL2 还激活 p38α 和 p38δ，以驱动中性粒细胞中各种炎症介质的产生。我们将讨论这一发现对各种炎症性疾病的意义。
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