伊朗6至18岁学生对乙肝疫苗反应的评估。
Evaluation of response to hepatitis B vaccine in Iranian 6-18-year-old students.
作者信息
Jouneghani Alizamen Salehifard, Chaleshtori Morteza Hashemzadeh, Khoshdel Abolfazl, Kheiri Soleiman, Farrokhi Effat, Khalafian Pooran, Aliyari Zahra
机构信息
Department of Pediatrics, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
出版信息
J Res Med Sci. 2017 Oct 31;22:116. doi: 10.4103/jrms.JRMS_204_17. eCollection 2017.
BACKGROUND
Hepatitis B is a dangerous disease with high morbidity and mortality rates all around the world. Vaccination is the most important way to its prevention and control. This cross-sectional study was carried out to study the levels of immunogenicity to hepatitis B vaccine in students.
MATERIALS AND METHODS
Six hundred and forty-four students aged 6-18 years including 316 girls and 328 boys were selected from the Chaharmahal Va Bakhtiari province. Selected students had been received three doses of recombinant vaccine (0, 1, and 6 months). Blood samples were taken and the titers of hepatitis B surface antigen were studied.
RESULTS
From a total of 644 students, 396 (61.5%) had a titer lesser than 10 mIu/ml and 248 (38.5%) had a titer higher than 10 mIu/ml. Therefore, the level of respond to vaccine with 95% confidence was 38.5% (34.7%-42.4%). Levels of respond to vaccine were related to age, body mass index (BMI), and educational level and were not related to sex and habit of students.
CONCLUSION
Reverse significant relation was seen between the respond to vaccine and age and BMI in a way which the titers of antibody were lower in students with higher age and BMI.
背景
乙型肝炎是一种在全球范围内发病率和死亡率都很高的危险疾病。接种疫苗是防控该病的最重要方式。本横断面研究旨在探讨学生对乙肝疫苗的免疫原性水平。
材料与方法
从恰哈马哈勒-巴赫蒂亚里省选取了644名6至18岁的学生，其中包括316名女生和328名男生。所选学生均已接种三剂重组疫苗（0、1和6个月）。采集血样并研究乙肝表面抗原滴度。
结果
在总共644名学生中，396名（61.5%）的滴度低于10 mIu/ml，248名（38.5%）的滴度高于10 mIu/ml。因此，疫苗接种反应水平在95%置信区间为38.5%（34.7%-42.4%）。疫苗接种反应水平与年龄、体重指数（BMI）和教育程度有关，与学生的性别和习惯无关。
结论
疫苗接种反应与年龄和BMI呈负相关，即年龄和BMI较高的学生抗体滴度较低。
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