1型神经纤维瘤病伴或不伴视神经通路胶质瘤患者视网膜神经纤维层厚度和神经节细胞复合体的测量：病例系列研究

Measurements of Retinal Nerve Fiber Thickness and Ganglion Cell Complex in Neurofibromatosis Type 1, with and Without Optic Pathway Gliomas: A Case Series.

作者信息

Sahinoglu-Keskek Nedime, Altan-Yaycioglu Rana, Canan Handan, Coban-Karatas Muge, Erbay Ayşe, Yazıcı Nalan, Alkan Ozlem

机构信息

a Department of Ophthalmology, Faculty of Medicine , Baskent University, Adana Training and Research Center , Adana , Turkey.

b Department of Pediatric Hematology and Oncology, Faculty of Medicine , Baskent University, Adana Training and Research Center , Adana , Turkey.

出版信息

Curr Eye Res. 2018 Mar;43(3):424-427. doi: 10.1080/02713683.2017.1408130. Epub 2017 Nov 29.

DOI:10.1080/02713683.2017.1408130

PMID:29185816

Abstract

PURPOSE

The aim of this study was to investigate differences in retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses in neurofibromatosis 1 (NF1) cases, with and without optic pathway gliomas (OPGs).

MATERIALS AND METHODS

In total, 33 eyes of 33 subjects were evaluated in this prospective observational case series. Twenty-one patients with a diagnosis of NF1 were enrolled. Patients with NF1 and OPGs were included in Group 1 (n = 9), and patients with NF1 without OPGs were included in Group 2 (n = 12). The control group (Group 3) was comprised of 12 age- and sex-matched subjects with no history of ophthalmic or systemic diseases. All of the subjects underwent complete ophthalmic examinations, including best-corrected visual acuity (BCVA), slit lamp microscopy, and indirect ophthalmoscopy. Additionally, optical coherence tomography (OCT) measurements were obtained.

RESULTS

There were no statistically significant between-group differences in age and sex (p = 0.227 and 0.986, respectively). The average RNFL thickness in Group 1 (NF1 patients with OPGs) was significantly lower than in Groups 2 and 3 (86.6 ± 22.5, 107.4 ± 6.65, and 108.4 ± 5.05 µm, respectively; p = 0.001). Furthermore, the average GCC thickness in Group 1 was significantly lower than in Groups 2 and 3 (78.6 ± 16.3, 94.8 ± 3.55, and 94.9 ± 3.82 µm, respectively; p < 0.001).

CONCLUSIONS

Both RNFL and GCC thicknesses were significantly lower in NF1 patients with OPGs. The use of OCT to quantify damage to the visual pathway may enable earlier detection of OPGs in NF1 patients.

摘要

目的

本研究旨在调查患有和未患有视神经通路胶质瘤（OPG）的1型神经纤维瘤病（NF1）患者视网膜神经纤维层（RNFL）和神经节细胞复合体（GCC）厚度的差异。

材料与方法

在这个前瞻性观察病例系列中，共评估了33名受试者的33只眼睛。纳入了21名诊断为NF1的患者。患有NF1和OPG的患者被纳入第1组（n = 9），患有NF1但无OPG的患者被纳入第2组（n = 12）。对照组（第3组）由12名年龄和性别匹配且无眼科或全身性疾病史的受试者组成。所有受试者均接受了全面的眼科检查，包括最佳矫正视力（BCVA）、裂隙灯显微镜检查和间接检眼镜检查。此外，还进行了光学相干断层扫描（OCT）测量。

结果

年龄和性别在组间无统计学显著差异（p分别为0.227和0.986）。第1组（患有OPG的NF1患者）的平均RNFL厚度显著低于第2组和第3组（分别为86.6±22.5、107.4±6.65和108.4±5.05μm；p = 0.001）。此外，第1组的平均GCC厚度显著低于第2组和第3组（分别为78.6±16.3、94.8±3.55和94.9±3.82μm；p < 0.001）。