de Thézy Albane, Lafargue Aurélie, d'Arailh Lydie, Dijos Marina, Leroux Lionel, Salles Nathalie, Rainfray Muriel
Service de gériatrie, Hupifo, AP-HP, Hôpital Sainte Périne, Paris, France.
Service de gériatrie, Hôpital Xavier Arnozan, CHU Hôpitaux de Bordeaux, Pessac, France.
Geriatr Psychol Neuropsychiatr Vieil. 2017 Dec 1;15(4):357-363. doi: 10.1684/pnv.2017.0697.
Aortic stenosis (AS) may soon become a significant public health issue. Referring elderly suffering from aortic stenosis for a transcatheter aortic valve implantation (TAVI) versus surgical valve replacement might be difficult and requires a multidisciplinary staff. G8 is a geriatric screening scale for frailty, validated in oncogeriatry. We study sensibility and specificity of G8 used by cardiologists in comparison to a comprehensive geriatric assessment (CGA) performed by geriatrician. Prospective study, from February to July 2015, in Bordeaux university Hospital, France. Every elderly admitted for a TAVI had a G8 scale performed by cardiologist and CGA by a geriatrician in blind. Comorbidities were assessed using Cumulative Illness Rating Scale in his geriatric version (CIRS-G). CGA was abnormal if: MMSE <24/30 or GDS ≥7/15 or ADL ≤5/6 or IADL ≤7/8 or TUG ≥20 seconds or if malnutrition was noticed. G8 was abnormal if ≤14/17. We calculated sensibility, specificity, positive and negative predictive value in comparison to gold-standard CGA. 49 patients were included (55.1% women, mean age 84.8 years old). Nearly half of the patients (48.96%) had multiple comorbidities (CIRS G score >3 for at least three items excluding the cardiology item). 38 CGA were abnormal (77.55%) and 41 G8 (83.67%). G8 had a sensibility of 100% (IC 95% [0.9-1]), a specificity of 72.7% (IC 95% [0.43-0.9]), a positive predictive value of 92.6% and a negative prospective value of 100% (IC: 95%). G8 scale seems to be an efficient geriatric screening tool for frailty in elderly undergoing TAVI in comparison to CGA. Simple and useful, G8 scale could be performed by cardiologists in older patients with AS for identifying patients with a geriatric risk profile in consultation before surgery. Further studies with bigger samples are needed to confirm these results.
主动脉瓣狭窄(AS)可能很快会成为一个重大的公共卫生问题。对于患有主动脉瓣狭窄的老年人,决定采用经导管主动脉瓣植入术(TAVI)还是外科瓣膜置换术可能比较困难,且需要多学科团队协作。G8是一种用于评估虚弱程度的老年筛查量表,已在老年肿瘤学领域得到验证。我们研究了心脏病专家使用的G8量表与老年病科医生进行的全面老年评估(CGA)相比的敏感性和特异性。这是一项前瞻性研究,于2015年2月至7月在法国波尔多大学医院开展。每一位因TAVI入院的老年人都由心脏病专家进行G8量表评估,并由老年病科医生在不知情的情况下进行CGA。使用老年版累积疾病评定量表(CIRS-G)评估合并症。若出现以下情况,则CGA为异常:简易精神状态检查表(MMSE)<24/30或老年抑郁量表(GDS)≥7/15或日常生活活动能力(ADL)≤5/6或工具性日常生活活动能力(IADL)≤7/8或定时起立行走测试(TUG)≥20秒,或者发现存在营养不良。若G8≤14/17,则G8为异常。我们将与金标准CGA相比,计算敏感性、特异性、阳性预测值和阴性预测值。共纳入49例患者(女性占55.1%,平均年龄84.8岁)。近一半患者(48.96%)患有多种合并症(CIRS G评分中至少三项不包括心脏病项目的得分>3)。38例CGA异常(77.55%),41例G8异常(83.67%)。G8的敏感性为100%(95%置信区间[0.9 - 1]),特异性为72.7%(95%置信区间[0.43 - 0.9]),阳性预测值为92.6%,阴性预测值为100%(95%置信区间)。与CGA相比,G8量表似乎是一种用于接受TAVI的老年人虚弱程度评估的有效筛查工具。G8量表简单实用,心脏病专家可对患有AS的老年患者进行评估,以便在术前会诊时识别具有老年风险特征的患者。需要进一步开展更大样本量的研究来证实这些结果。