Bortolotti U, Milano A, Mazzucco A, Guerra F, Magni A, Santini F, Gallucci V
Department of Cardiovascular Surgery, University of Padova Medical School, Italy.
J Thorac Cardiovasc Surg. 1989 Mar;97(3):415-20.
From May 1983 to July 1987 a total of 153 Hancock II porcine bioprostheses have been implanted in 130 patients with a mean age of 59 +/- 8 years (range 29 to 76 years). Mitral valve replacement was performed in 72 patients, aortic valve replacement in 35, and mitral-aortic valve replacement in 23. Cumulative follow-up of 121 survivors is 223 patient-years and 100% complete (range 0.4 to 4.5 years). The actuarial survival rate at 4 years is 88% +/- 8% for mitral, 86% +/- 7.8% for aortic, and 84% +/- 8% for mitral-aortic valve replacement. Minor thomboembolism occurred in two patients (0.9% +/- 0.6%/pt-yr) with an actuarial freedom from emboli at 4 years of 100% for mitral, 96% +/- 3.7% for aortic, and 91% +/- 8.6% for mitral-aortic valve replacement. Anticoagulant-related hemorrhage occurred in 10 patients (4.4% +/- 1.4%/pt-yr) with an actuarial freedom at 4 years of 90% +/- 4.8% for mitral, 89% +/- 5.8% for aortic, and 84% +/- 10.6% for mitral-aortic valve replacement. Failure of the porcine bioprosthesis was observed in three patients with an actuarial freedom at 4 years of 96% +/- 3.6% for aortic, 91% +/- 8% for mitral, and 91% +/- 8.6% for mitral-aortic valve replacement. Actuarial freedom from all porcine bioprosthesis-related complications at 4 years is 85.7% +/- 6.6% for aortic, 79% +/- 9% for mitral, and 70% +/- 13% for mitral-aortic valve replacement. No instances of primary tissue failure occurred.(ABSTRACT TRUNCATED AT 250 WORDS)
1983年5月至1987年7月，共153个汉考克二代猪生物瓣膜被植入130例患者体内，患者平均年龄59±8岁（范围29至76岁）。72例患者接受二尖瓣置换，35例接受主动脉瓣置换，23例接受二尖瓣 - 主动脉瓣置换。121例幸存者的累积随访时间为223患者 - 年，且随访完整率达100%（范围0.4至4.5年）。二尖瓣置换术后4年的精算生存率为88%±8%，主动脉瓣置换为86%±7.8%，二尖瓣 - 主动脉瓣置换为84%±8%。2例患者发生轻微血栓栓塞（0.9%±0.6%/患者 - 年），二尖瓣置换术后4年无栓塞的精算自由度为100%，主动脉瓣置换为96%±3.7%，二尖瓣 - 主动脉瓣置换为91%±8.6%。10例患者发生抗凝相关出血（4.4%±1.4%/患者 - 年），二尖瓣置换术后4年无出血的精算自由度为90%±4.8%，主动脉瓣置换为89%±5.8%，二尖瓣 - 主动脉瓣置换为84%±10.6%。3例患者观察到猪生物瓣膜失效，主动脉瓣置换术后4年无失效的精算自由度为96%±3.6%，二尖瓣置换为91%±8%，二尖瓣 - 主动脉瓣置换为91%±8.6%。主动脉瓣置换术后4年无所有猪生物瓣膜相关并发症的精算自由度为85.7%±6.6%，二尖瓣置换为79%±9%，二尖瓣 - 主动脉瓣置换为70%±13%。未发生原发性组织失效情况。（摘要截选至250字）
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