Kanninen Katja, Malm Tarja
Duodecim. 2016;132(21):1957-63.
Exosomes are vesicles bordered by a lipid membrane and containing various molecules. Virtually all cells in the body are able to secrete exosomes that can be carried long distances within the body and are capable of altering the function of the receiving cell by means of the contained molecules. The amount and composition of molecules contained in exosomes have been shown to differ in various diseases, whereby exosomes can be utilized in diagnostic purposes. Furthermore, it may be possible to use exosomes for the treatment of diseases, because they can carry therapeutic molecules in the body.
外泌体是一种由脂质膜包裹且含有多种分子的囊泡。实际上,体内所有细胞都能够分泌外泌体,这些外泌体可在体内远距离运输,并能够通过所含分子改变受体细胞的功能。研究表明,不同疾病中外泌体所含分子的数量和组成存在差异,因此外泌体可用于诊断目的。此外,外泌体有可能用于疾病治疗,因为它们可以在体内携带治疗性分子。