Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Cell Death Dis. 2017 Nov 30;8(11):e3174. doi: 10.1038/cddis.2017.516.
Aberrant differentiation of keratinocytes has been demonstrated to be associated with a number of skin diseases. A growing number of studies have showed that long noncoding RNAs (lncRNAs) have an important part in gene regulation, however, the role of lncRNAs in keratinocyte differentiation remains to be largely unknown. In the present study, we demonstrated that lncRNA-H19 act as an endogenous 'sponge', which binds directly to miR-130b-3p and therefore inhibits its activity on Dsg1. MiR-130b-3p was illustrated to inhibit keratinocyte differentiation by targeting Dsg1. H19 regulates Dsg1 expression and the consequent keratinocyte differentiation through miR-130b-3p. Our study casts light on a novel regulatory model of keratinocyte differentiation, which may provide new therapeutic targets of skin diseases.
异常的角质形成细胞分化已被证明与许多皮肤疾病有关。越来越多的研究表明，长链非编码 RNA（lncRNA）在基因调控中具有重要作用，然而，lncRNA 在角质形成细胞分化中的作用在很大程度上仍然未知。在本研究中，我们证明了 lncRNA-H19 作为一种内源性“海绵”，直接结合 miR-130b-3p，从而抑制其对 Dsg1 的活性。研究表明 miR-130b-3p 通过靶向 Dsg1 抑制角质形成细胞分化。H19 通过 miR-130b-3p 调节 Dsg1 表达和随后的角质形成细胞分化。我们的研究揭示了角质形成细胞分化的一种新的调控模型，这可能为皮肤疾病提供新的治疗靶点。
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